The 2015–16 USC Trojans men's basketball team represented the University of Southern California during the 2015–16 NCAA Division I men's basketball season. They were led by third-year head coach Andy Enfield. They played their home games at the Galen Center and were members of the Pac-12 Conference. They finished the season 21–13, 9–9 in Pac-12 play to finish in a three-way tie for sixth place. They defeated UCLA in the first round of the Pac-12 tournament to advance to the quarterfinals where they lost to Utah. They received an at-large bid to the NCAA tournament where they lost in the first round to Providence.