About: Knotted protein

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Knotted proteins are proteins whose backbones entangle themselves in a knot. One can imagine pulling a protein chain from both termini, as though pulling a string from both ends. When a knotted protein is “pulled” from both termini, it does not get disentangled. Knotted proteins are very rare, making up only about one percent of the proteins in the Protein Data Bank, and their folding mechanisms and function are not well understood. Although there are experimental and theoretical studies that hint to some answers, systematic answers to these questions have not yet been found.

Attributes	Values
rdf:type	yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins
rdfs:label	Knotted protein (en) Proteína atada (pt)
rdfs:comment	Matematicamente, um nó é definido como um subconjunto de pontos tridimensionais homeomórficos a um círculo. De acordo com esta definição, um nó só fazem sentidos para um laço próximo. Se escolher um ponto no espaço a uma distância infinita e conectar-se ao N e C terminais, respectivamente através de uma ligação virtual, a proteína pode ser tratada como um laço virtual perto. Portanto, o laço é detectado como próximo nó topologia e podemos citar como a proteína nó. (pt) Knotted proteins are proteins whose backbones entangle themselves in a knot. One can imagine pulling a protein chain from both termini, as though pulling a string from both ends. When a knotted protein is “pulled” from both termini, it does not get disentangled. Knotted proteins are very rare, making up only about one percent of the proteins in the Protein Data Bank, and their folding mechanisms and function are not well understood. Although there are experimental and theoretical studies that hint to some answers, systematic answers to these questions have not yet been found. (en)
foaf:depiction
dcterms:subject	Proteins Computational biology
Wikipage page ID	32890629 (xsd:integer)
Wikipage revision ID	1100925646 (xsd:integer)
Link from a Wikipage to another Wikipage	Hopf link Composite knot Complex lasso proteins Protein Data Bank 63 knot Proteins Cystine knot Figure-eight knot (mathematics) Protein Computational biology Homeomorphism Trefoil knot Solomon's knot Knot (mathematics) Stevedore knot (mathematics) TRNA (cytidine34-2'-O)-methyltransferase Three-twist knot Web servers
Link from a Wikipage to an external page	http://knotprot.cent.uw.edu.pl/ http://knots.mit.edu/ https://alphaknot.cent.uw.edu.pl/browse/%3Fall=&cats=Knot&organisms=&knotTypes=3_1%233_1 https://web.archive.org/web/20110824133833/http:/pknot.life.nctu.edu.tw/
sameAs	Knotted protein Knotted protein Knotted protein Knotted protein Knotted protein
dbp:wikiPageUsesTemplate	dbt:Reflist
thumbnail	wiki-commons:Special:FilePath/Smoothed_knot.gif?width=300
has abstract	Knotted proteins are proteins whose backbones entangle themselves in a knot. One can imagine pulling a protein chain from both termini, as though pulling a string from both ends. When a knotted protein is “pulled” from both termini, it does not get disentangled. Knotted proteins are very rare, making up only about one percent of the proteins in the Protein Data Bank, and their folding mechanisms and function are not well understood. Although there are experimental and theoretical studies that hint to some answers, systematic answers to these questions have not yet been found. Although number of computational methods have been developed to detect protein knots, there are still no completely automatic methods to detect protein knots without necessary manual intervention due to the missing residues or chain breaks in the X-ray structures or the nonstandard PDB formats. Most of the knots discovered in proteins are deep trefoil (31) knots. Figure eight knots (41), three-twist knots (52), and Stevedore knots (61) have also been discovered. Recently, use of machine learning techniques for predicting protein structure, resulted in highly accurate prediction of 6₃ knot. Furthermore using same techniques, composite knots (namely 31#31) were found. (en) Matematicamente, um nó é definido como um subconjunto de pontos tridimensionais homeomórficos a um círculo. De acordo com esta definição, um nó só fazem sentidos para um laço próximo. Se escolher um ponto no espaço a uma distância infinita e conectar-se ao N e C terminais, respectivamente através de uma ligação virtual, a proteína pode ser tratada como um laço virtual perto. Portanto, o laço é detectado como próximo nó topologia e podemos citar como a proteína nó. (pt)
gold:hypernym	Proteins
prov:wasDerivedFrom	wikipedia-en:Knotted_protein?oldid=1100925646&ns=0
page length (characters) of wiki page	19762 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Knotted_protein
is Link from a Wikipage to another Wikipage of	Complex lasso proteins Trefoil knot fold Ribosome Molecular knot
is foaf:primaryTopic of	wikipedia-en:Knotted_protein

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