Choclo orthohantavirus (CHOV) is a single-stranded, negative-sense RNA zoonotic New World hantavirus. It was first isolated in 1999 in western Panama. The finding marked the first time Hantavirus pulmonary syndrome (HPS) was found in Central America. During this outbreak, a high seroprevalence was found among the general population, suggesting that this virus has an extremely low pathogenicity and causes sub-clinical to mild symptoms. This was confirmed in a study that infected hamsters with CHOV. All of the hamsters tested positive for CHOV, but none exhibited any symptoms.
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