The 2021 Premier Volleyball League Open Conference was the tenth conference of the Premier Volleyball League (37th conference of the former Shakey's V-League) and its first conference as a professional league. The conference started on July 17, 2021 and ended on August 13, 2021, at the PCV Socio-Civic and Cultural Center in Bacarra, Ilocos Norte in a bubble. The PVL has been approved by the Inter-Agency Task Force for the Management of Emerging Infectious Diseases (IATF-EID) to begin team practices to be followed by the official start of the 2021 season.