The 2021 Calgary Stampeders season was the 63rd season for the team in the Canadian Football League and their 76th overall. The Stampeders qualified for the playoffs for the 16th straight year following their week 15 victory over the BC Lions on November 12, 2021. However, the team lost the West Semi-Final in double overtime to the Saskatchewan Roughriders by a score of 33–30. The 2021 season was Dave Dickenson's fifth season as head coach and John Hufnagel's 13th season as general manager.