1-(2-Diphenyl)piperazine, also known as RA-7, is a drug which acts as a potent and selective antagonist at the 5HT7 serotonin receptor. It was discovered as an active metabolite of the synthetic 5-HT7 agonists LP-12 and LP-211, and unexpectedly turned out to be a potent antagonist with selectivity approaching that of the parent molecules, despite its much simpler structure.
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