About: Signal peptide peptidase

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In molecular biology, the Signal Peptide Peptidase (SPP) is a type of protein that specifically cleaves parts of other proteins. It is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). Its sequences is highly conserved in different vertebrate species. SPP cleaves remnant signal peptides left behind in membrane by the action of signal peptidase and also plays key roles in immune surveillance and the maturation of certain viral proteins.

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dbo:abstract
  • Signalpeptidasen, auch Signalasen, sind proteinspaltende Enzyme (Proteasen), die an der Membran des Endoplasmatischen Retikulums (ER) innerhalb der Zelle lokalisiert sind. Die Signalpeptidase erkennt spezielle Aminosäuresequenzen (Signalsequenzen) innerhalb eines Proteins. Sie spaltet im Lumen des ER das Signalpeptid von der restlichen Polypeptidkette ab. (de)
  • In molecular biology, the Signal Peptide Peptidase (SPP) is a type of protein that specifically cleaves parts of other proteins. It is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). Its sequences is highly conserved in different vertebrate species. SPP cleaves remnant signal peptides left behind in membrane by the action of signal peptidase and also plays key roles in immune surveillance and the maturation of certain viral proteins. (en)
dbo:symbol
  • Peptidase_A24
  • Peptidase_A22B
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  • 6321288 (xsd:integer)
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  • 8776 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1028761806 (xsd:integer)
dbo:wikiPageWikiLink
dbp:interpro
  • IPR000045 (en)
  • IPR007369 (en)
dbp:merops
  • A22 (en)
  • A24 (en)
dbp:name
  • Peptidase_A24 (en)
  • Peptidase_A22B (en)
dbp:opmFamily
  • 244 (xsd:integer)
dbp:opmProtein
  • 3 (xsd:integer)
dbp:pfam
  • PF01478 (en)
  • PF04258 (en)
dbp:pfamClan
  • CL0130 (en)
dbp:symbol
  • Peptidase_A24 (en)
  • Peptidase_A22B (en)
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dcterms:subject
gold:hypernym
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rdfs:comment
  • Signalpeptidasen, auch Signalasen, sind proteinspaltende Enzyme (Proteasen), die an der Membran des Endoplasmatischen Retikulums (ER) innerhalb der Zelle lokalisiert sind. Die Signalpeptidase erkennt spezielle Aminosäuresequenzen (Signalsequenzen) innerhalb eines Proteins. Sie spaltet im Lumen des ER das Signalpeptid von der restlichen Polypeptidkette ab. (de)
  • In molecular biology, the Signal Peptide Peptidase (SPP) is a type of protein that specifically cleaves parts of other proteins. It is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). Its sequences is highly conserved in different vertebrate species. SPP cleaves remnant signal peptides left behind in membrane by the action of signal peptidase and also plays key roles in immune surveillance and the maturation of certain viral proteins. (en)
rdfs:label
  • Signalpeptidase (de)
  • Signal peptide peptidase (en)
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