The 2018–19 season was Guadalajara's third competitive season and third season in the Liga MX Femenil, the top flight of Mexican women's football. The season started under a new manager, Ramón Villa Zevallos, who won the Clausura 2019 tournament with Tigres UANL. Guadalajara finished fifth on the Apertura tournament, qualifying for the playoffs; but were eliminated right away on quarterfinals by rivals América.