State Route 207 (SR 207) is a 32-mile-long (51 km) northwest-southeast state highway in the southern portion of the U.S. state of Ohio. The first northern terminus of SR 207 is at a roundabout with SR 159 nearly four miles (6.4 km) north of Chillicothe. Its second northern terminus is in Mount Sterling, following a 0.33-mile (0.53 km) long concurrence with U.S. Route 62 (US 62) and SR 3, at the intersection where they meet SR 56. The route has two north ends, because after the intersection with US 23 the route's directions flip. Southbound 1, heading toward SR 159, is labeled northbound. Southbound 2, heading toward US 23/SR 104, is labeled northbound as well.