State Route 104 (SR 104) is a north–south highway in Southern Ohio. Its southern terminus is at U.S. Route 23 (US 23) in Portsmouth, Ohio and its northern terminus is at US 33 in Columbus. The route passes through or close to the towns of Portsmouth, Waverly, Chillicothe, Grove City, and Columbus. From Waverly to Chillicothe, it overlaps US 23. Though officially a north-south highway for its entire length, SR 104 is also signed east-west through Columbus.