State Route 180 (SR 180) is a 29.55-mile (47.56 km) long east–west state highway in the southern portion of the U.S. state of Ohio. SR 180 has its western terminus at a Roundabout with SR 159 nearly 5 miles (8.0 km) northeast of Chillicothe. Its eastern terminus is at a diamond interchange with the U.S. Route 33 (US 33) expressway approximately 3.75 miles (6.04 km) northwest of Logan.