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The zone of polarizing activity (ZPA) is an area of mesenchyme that contains signals which instruct the developing limb bud to form along the anterior/posterior axis. Limb bud is undifferentiated mesenchyme enclosed by an ectoderm covering. Eventually, the limb bud develops into bones, tendons, muscles and joints. Limb bud development relies not only on the ZPA, but also many different genes, signals, and a unique region of ectoderm called the apical ectodermal ridge (AER). Research by Saunders and Gasseling in 1948 identified the AER and its subsequent involvement in proximal distal outgrowth. Twenty years later, the same group did transplantation studies in chick limb bud and identified the ZPA. It wasn't until 1993 that Todt and Fallon showed that the AER and ZPA are dependent on each o

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  • La Zona de actividad polarizante (ZPA, por sus siglas en inglés: Zone of Polarizing Activity) es un área mesenquimatosa que contiene señales que conducen a la construcción de un a lo largo del eje antero-posterior. Este esbozo consiste en mesénquima indiferenciado cubierto por ectodermo. Eventualmente, el esbozo de extremidad se desarrolla formando huesos, tendones, músculos y articulaciones. Su desarrollo depende no solo de la ZPA, sino también de diferentes genes, señales, y una región única del ectodermo denominada cresta ectodérmica apical (AER).Los trabajos de Saunders and Gasseling en 1948 identificaron la AER y su posterior implicación en el crecimiento próximo-distal.​ Veinte años después, el mismo grupo efectuó estudios de trasplante en esbozos de extremidad de pollo e identificaron la ZPA. No fue hasta 1987 cuando Todt y Fallon mostraron que la AER y la ZPA son interdependientes.​ (es)
  • The zone of polarizing activity (ZPA) is an area of mesenchyme that contains signals which instruct the developing limb bud to form along the anterior/posterior axis. Limb bud is undifferentiated mesenchyme enclosed by an ectoderm covering. Eventually, the limb bud develops into bones, tendons, muscles and joints. Limb bud development relies not only on the ZPA, but also many different genes, signals, and a unique region of ectoderm called the apical ectodermal ridge (AER). Research by Saunders and Gasseling in 1948 identified the AER and its subsequent involvement in proximal distal outgrowth. Twenty years later, the same group did transplantation studies in chick limb bud and identified the ZPA. It wasn't until 1993 that Todt and Fallon showed that the AER and ZPA are dependent on each other. (en)
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  • ZPA (en)
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  • The apical ectodermal ridge is a thickened epithelium at the most distal end of the limb bud. The zone of polarizing activity is at the posterior part of the limb bud. (en)
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  • zona activitatis polarisantis (en)
dbp:name
  • Zone of polarizing activity (en)
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  • La Zona de actividad polarizante (ZPA, por sus siglas en inglés: Zone of Polarizing Activity) es un área mesenquimatosa que contiene señales que conducen a la construcción de un a lo largo del eje antero-posterior. Este esbozo consiste en mesénquima indiferenciado cubierto por ectodermo. Eventualmente, el esbozo de extremidad se desarrolla formando huesos, tendones, músculos y articulaciones. Su desarrollo depende no solo de la ZPA, sino también de diferentes genes, señales, y una región única del ectodermo denominada cresta ectodérmica apical (AER).Los trabajos de Saunders and Gasseling en 1948 identificaron la AER y su posterior implicación en el crecimiento próximo-distal.​ Veinte años después, el mismo grupo efectuó estudios de trasplante en esbozos de extremidad de pollo e identifica (es)
  • The zone of polarizing activity (ZPA) is an area of mesenchyme that contains signals which instruct the developing limb bud to form along the anterior/posterior axis. Limb bud is undifferentiated mesenchyme enclosed by an ectoderm covering. Eventually, the limb bud develops into bones, tendons, muscles and joints. Limb bud development relies not only on the ZPA, but also many different genes, signals, and a unique region of ectoderm called the apical ectodermal ridge (AER). Research by Saunders and Gasseling in 1948 identified the AER and its subsequent involvement in proximal distal outgrowth. Twenty years later, the same group did transplantation studies in chick limb bud and identified the ZPA. It wasn't until 1993 that Todt and Fallon showed that the AER and ZPA are dependent on each o (en)
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  • Zona de actividad polarizante (es)
  • Zone of polarizing activity (en)
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  • Zone of polarizing activity (en)
  • zona activitatis polarisantis (en)
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