About: Vav (protein)

An Entity of Type: SocialGroup107950920, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Vav is a family of proteins involved in cell signalling. They act as guanine nucleotide exchange factors (GEFs) for small G proteins of the Rho family. GEF activity is mediated via module of tandem DH-PH domains. Vav proteins also appear to exhibit GEF-independent functions. Although it was originally thought that Vav proteins would only be present in multicellular organisms, Vav family proteins have been observed in Choanoflagellates.

Property Value
dbo:abstract
  • Vav-Proteine sind GTP-Austauschfaktoren für Rho-GTPasen. Dadurch wirken sie in der Signalleitung von Zellen. In Säugezellen unterscheidet man drei verschiedene Vav-Proteine. Während Vav-1 auf hematopoetische Zellen beschränkt ist, werden Vav-2 und Vav-3 in verschiedenen Zelltypen exprimiert. Alle drei enthalten eine DH (Dbl-homology)-Domäne, die den GTP-Austausch in kleinen Rho-GTPasen katalysiert, eine PH (pleckstrin-homology)-Domäne und eine SH2-Domäne, die von zwei SH3-Domänen eingefasst ist. (de)
  • Vav is a family of proteins involved in cell signalling. They act as guanine nucleotide exchange factors (GEFs) for small G proteins of the Rho family. GEF activity is mediated via module of tandem DH-PH domains. Vav proteins also appear to exhibit GEF-independent functions. Although it was originally thought that Vav proteins would only be present in multicellular organisms, Vav family proteins have been observed in Choanoflagellates. (en)
dbo:wikiPageID
  • 18877021 (xsd:integer)
dbo:wikiPageLength
  • 1744 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1095281692 (xsd:integer)
dbo:wikiPageWikiLink
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • Vav-Proteine sind GTP-Austauschfaktoren für Rho-GTPasen. Dadurch wirken sie in der Signalleitung von Zellen. In Säugezellen unterscheidet man drei verschiedene Vav-Proteine. Während Vav-1 auf hematopoetische Zellen beschränkt ist, werden Vav-2 und Vav-3 in verschiedenen Zelltypen exprimiert. Alle drei enthalten eine DH (Dbl-homology)-Domäne, die den GTP-Austausch in kleinen Rho-GTPasen katalysiert, eine PH (pleckstrin-homology)-Domäne und eine SH2-Domäne, die von zwei SH3-Domänen eingefasst ist. (de)
  • Vav is a family of proteins involved in cell signalling. They act as guanine nucleotide exchange factors (GEFs) for small G proteins of the Rho family. GEF activity is mediated via module of tandem DH-PH domains. Vav proteins also appear to exhibit GEF-independent functions. Although it was originally thought that Vav proteins would only be present in multicellular organisms, Vav family proteins have been observed in Choanoflagellates. (en)
rdfs:label
  • Vav-Proteine (de)
  • Vav (protein) (en)
owl:sameAs
prov:wasDerivedFrom
foaf:isPrimaryTopicOf
is dbo:wikiPageDisambiguates of
is dbo:wikiPageWikiLink of
is foaf:primaryTopic of
Powered by OpenLink Virtuoso    This material is Open Knowledge     W3C Semantic Web Technology     This material is Open Knowledge    Valid XHTML + RDFa
This content was extracted from Wikipedia and is licensed under the Creative Commons Attribution-ShareAlike 3.0 Unported License