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- Les Upstream Activator Sequences sont des séquences d'ADN présent dans les levures. Celle-ci sont analogues aux enhancer des eucaryotes supérieur mais ne fonctionnent pas quand elles sont en aval du promoteur. (Il faut qu'elles soient en amont)
* Portail de la biologie cellulaire et moléculaire (fr)
- An upstream activating sequence or upstream activation sequence (UAS) is a cis-acting regulatory sequence. It is distinct from the promoter and increases the expression of a neighbouring gene. Due to its essential role in activating transcription, the upstream activating sequence is often considered to be analogous to the function of the enhancer in multicellular eukaryotes. Upstream activation sequences are a crucial part of induction, enhancing the expression of the protein of interest through increased transcriptional activity. The upstream activation sequence is found adjacently upstream to a minimal promoter (TATA box) and serves as a binding site for transactivators. If the transcriptional transactivator does not bind to the UAS in the proper orientation then transcription cannot begin. To further understand the function of an upstream activation sequence, it is beneficial to see its role in the cascade of events that lead to transcription activation. The pathway begins when activators bind to their target at the UAS recruiting a mediator. A TATA-binding protein subunit of a transcription factor then binds to the TATA box, recruiting additional transcription factors. The mediator then recruits RNA polymerase II to the pre-initiation complex. Once initiated, RNA polymerase II is released from the complex and transcription begins. (en)
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- Les Upstream Activator Sequences sont des séquences d'ADN présent dans les levures. Celle-ci sont analogues aux enhancer des eucaryotes supérieur mais ne fonctionnent pas quand elles sont en aval du promoteur. (Il faut qu'elles soient en amont)
* Portail de la biologie cellulaire et moléculaire (fr)
- An upstream activating sequence or upstream activation sequence (UAS) is a cis-acting regulatory sequence. It is distinct from the promoter and increases the expression of a neighbouring gene. Due to its essential role in activating transcription, the upstream activating sequence is often considered to be analogous to the function of the enhancer in multicellular eukaryotes. Upstream activation sequences are a crucial part of induction, enhancing the expression of the protein of interest through increased transcriptional activity. The upstream activation sequence is found adjacently upstream to a minimal promoter (TATA box) and serves as a binding site for transactivators. If the transcriptional transactivator does not bind to the UAS in the proper orientation then transcription cannot beg (en)
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- Upstream Activator Sequence (fr)
- Upstream activating sequence (en)
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