About: Trifluridine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Trifluridine (also called trifluorothymidine; abbreviation TFT or FTD) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name Viroptic by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by , which is wholly owned by King Pharmaceuticals. Trifluridine was approved for medical use in 1980. It is also a component of the anti-cancer drug trifluridine/tipiracil, which is taken by mouth.

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dbo:abstract
  • ثلاثي الفلوريدين (بالإنجليزية: Trifluridine)‏ هو دواء يُستعمل في علاج: * هربس * التهاب القرنية بفيروس الهربس البسيط (ar)
  • Trifluridin (abgekürzt TFT oder FTD; als Kombinationspräparat mit Tipiracil Lonsurf; Hersteller Servier) ist ein Arzneistoff aus der Gruppe der Nukleosidanaloga. Die Verbindung wurde 1970 vom US-Gesundheitsministerium patentiert und wird als Virostatikum verwendet. Die Kombination aus Trifluridin und Tipiracil im molaren Verhältnis 1:0,5 (vormals TAS-102) wird zur oralen Behandlung des metastasierten Kolorektalkarzinoms erwachsener Patienten nach diversen Vortherapien verwendet. In der EU ist sie seit April 2016 zugelassen. (de)
  • La Trifluridina (también llamada trifluorotimidina o TFT) es un fármaco antiviral contra el herpes. Trifluridina fue aprobada para uso médico en 1980.​ También es un componente con Tipiracil de una droga anticancerosa de vía oral. (es)
  • Trifluridine (also called trifluorothymidine; abbreviation TFT or FTD) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name Viroptic by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by , which is wholly owned by King Pharmaceuticals. Trifluridine was approved for medical use in 1980. It is also a component of the anti-cancer drug trifluridine/tipiracil, which is taken by mouth. (en)
  • Trifluridina conosciuta anche come trifluorotimidina oppure TFT, è un farmaco antivirale utilizzato come rimedio topico principalmente in oftalmologia per il trattamento delle infezioni da herpes simplex virus di tipo 1 (HSV-1) e di tipo 2 (HSV-2), e le infezioni da vaccinia virus. In vitro la molecola inibisce anche alcuni ceppi di adenovirus.In Italia la molecola è venduta dalla società farmaceutica Servier sotto forma di compresse in associazione con (che potenzia l'azione della trifluridina). Il nome commerciale di questa formulazione è Lonsurf. (it)
  • Trifluridine (trifluor-thymidine) is een geneesmiddel dat wordt gebruikt bij veroorzaakt door herpesvirussen. De werking berust er op dat bij de aanmaak van viraal DNA het nucleoside thymidine wordt vervangen door trifluor-thymidine waardoor de vermenigvuldiging van het virus geremd wordt. Het geneesmiddel aciclovir is echter het eerste keus middel bij deze infecties, trifluridine komt pas in aanmerking als aciclovir niet werkt of niet gegeven kan worden. Het wordt verkocht als oogdruppels 10 mg trifluridine per milliliter onder de merknaam TFT-Ophtiole. Trifluridine is op de markt sinds 1975. (nl)
  • 三氟胸苷(INN:trifluridine)(又称屈氟尿苷、曲氟尿苷、trifluorothymidine或TFT)是一種主要用于眼睛的反疱疹病毒科抗病毒药物。商品名称為Viroptic,原由葛兰素史克公司的前身Glaxo Wellcome所銷售。现在該商品名称由所拥有。三氟胸苷于1980年被批准用于医疗用途。它也是口服抗癌药物的一个组成部分。 (zh)
dbo:alternativeName
  • Viroptic; Lonsurf (+tipiracil) (en)
dbo:casNumber
  • 70-00-8
dbo:chEBI
  • 75179
dbo:chEMBL
  • 1129
dbo:drugbank
  • DB00432
dbo:fdaUniiCode
  • RMW9V5RW38
dbo:kegg
  • D00391
dbo:pubchem
  • 6256
dbo:thumbnail
dbo:wikiPageExternalLink
dbo:wikiPageID
  • 6051097 (xsd:integer)
dbo:wikiPageLength
  • 9496 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID
  • 1123057141 (xsd:integer)
dbo:wikiPageWikiLink
dbp:atcPrefix
  • S01 (en)
dbp:atcSuffix
  • AD02 (en)
dbp:bioavailability
  • Negligible ; (en)
  • ≥57% (en)
dbp:c
  • 10 (xsd:integer)
dbp:casNumber
  • 70 (xsd:integer)
dbp:chebi
  • 75179 (xsd:integer)
dbp:chembl
  • 1129 (xsd:integer)
dbp:chemspiderid
  • 6020 (xsd:integer)
dbp:drugbank
  • DB00432 (en)
dbp:eliminationHalfLife
  • 720.0
  • -7560.0
dbp:excretion
  • Mostly via urine (en)
dbp:f
  • 3 (xsd:integer)
dbp:h
  • 11 (xsd:integer)
dbp:iupacName
  • 1 (xsd:integer)
dbp:kegg
  • D00391 (en)
dbp:legalCa
  • Rx-only (en)
dbp:legalUs
  • Rx-only (en)
dbp:licenceEu
  • yes (en)
dbp:metabolism
dbp:n
  • 2 (xsd:integer)
dbp:o
  • 5 (xsd:integer)
dbp:pregnancyUs
  • C (en)
dbp:proteinBound
  • >96% (en)
dbp:pubchem
  • 6256 (xsd:integer)
dbp:routesOfAdministration
  • Eye drops; tablets (en)
dbp:smiles
  • FCC=1CNCN[C@@H]2O[C@@H]CO (en)
dbp:stdinchi
  • 1 (xsd:integer)
dbp:stdinchikey
  • VSQQQLOSPVPRAZ-RRKCRQDMSA-N (en)
dbp:synonyms
  • α,α,α-trifluorothymidine; 5-trifluromethyl-2′-deoxyuridine; FTD5-trifluoro-2′-deoxythymidine; TFT; CF3dUrd; FTD; F3TDR; F3Thd (en)
dbp:tradename
  • Viroptic; Lonsurf (en)
dbp:unii
  • RMW9V5RW38 (en)
dbp:verifiedfields
  • changed (en)
dbp:verifiedrevid
  • 470614687 (xsd:integer)
dbp:watchedfields
  • changed (en)
dbp:width
  • 150 (xsd:integer)
dbp:wikiPageUsesTemplate
dcterms:subject
gold:hypernym
rdf:type
rdfs:comment
  • ثلاثي الفلوريدين (بالإنجليزية: Trifluridine)‏ هو دواء يُستعمل في علاج: * هربس * التهاب القرنية بفيروس الهربس البسيط (ar)
  • Trifluridin (abgekürzt TFT oder FTD; als Kombinationspräparat mit Tipiracil Lonsurf; Hersteller Servier) ist ein Arzneistoff aus der Gruppe der Nukleosidanaloga. Die Verbindung wurde 1970 vom US-Gesundheitsministerium patentiert und wird als Virostatikum verwendet. Die Kombination aus Trifluridin und Tipiracil im molaren Verhältnis 1:0,5 (vormals TAS-102) wird zur oralen Behandlung des metastasierten Kolorektalkarzinoms erwachsener Patienten nach diversen Vortherapien verwendet. In der EU ist sie seit April 2016 zugelassen. (de)
  • La Trifluridina (también llamada trifluorotimidina o TFT) es un fármaco antiviral contra el herpes. Trifluridina fue aprobada para uso médico en 1980.​ También es un componente con Tipiracil de una droga anticancerosa de vía oral. (es)
  • Trifluridine (also called trifluorothymidine; abbreviation TFT or FTD) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name Viroptic by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by , which is wholly owned by King Pharmaceuticals. Trifluridine was approved for medical use in 1980. It is also a component of the anti-cancer drug trifluridine/tipiracil, which is taken by mouth. (en)
  • Trifluridina conosciuta anche come trifluorotimidina oppure TFT, è un farmaco antivirale utilizzato come rimedio topico principalmente in oftalmologia per il trattamento delle infezioni da herpes simplex virus di tipo 1 (HSV-1) e di tipo 2 (HSV-2), e le infezioni da vaccinia virus. In vitro la molecola inibisce anche alcuni ceppi di adenovirus.In Italia la molecola è venduta dalla società farmaceutica Servier sotto forma di compresse in associazione con (che potenzia l'azione della trifluridina). Il nome commerciale di questa formulazione è Lonsurf. (it)
  • Trifluridine (trifluor-thymidine) is een geneesmiddel dat wordt gebruikt bij veroorzaakt door herpesvirussen. De werking berust er op dat bij de aanmaak van viraal DNA het nucleoside thymidine wordt vervangen door trifluor-thymidine waardoor de vermenigvuldiging van het virus geremd wordt. Het geneesmiddel aciclovir is echter het eerste keus middel bij deze infecties, trifluridine komt pas in aanmerking als aciclovir niet werkt of niet gegeven kan worden. Het wordt verkocht als oogdruppels 10 mg trifluridine per milliliter onder de merknaam TFT-Ophtiole. Trifluridine is op de markt sinds 1975. (nl)
  • 三氟胸苷(INN:trifluridine)(又称屈氟尿苷、曲氟尿苷、trifluorothymidine或TFT)是一種主要用于眼睛的反疱疹病毒科抗病毒药物。商品名称為Viroptic,原由葛兰素史克公司的前身Glaxo Wellcome所銷售。现在該商品名称由所拥有。三氟胸苷于1980年被批准用于医疗用途。它也是口服抗癌药物的一个组成部分。 (zh)
rdfs:label
  • ثلاثي الفلوريدين (ar)
  • Trifluridin (de)
  • Trifluridina (es)
  • Trifluridina (it)
  • Trifluridine (nl)
  • Trifluridine (en)
  • 三氟胸苷 (zh)
owl:sameAs
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