About: Traumatic brain injury modeling

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Traumatic brain injury modeling replicates aspects of traumatic brain injury (TBI) as a method to better understand what physically happens to the brain. Researchers use a variety of models for this process, with different models able to replicate certain aspects of TBI while also producing their own limitations.

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  • Traumatic brain injury modeling replicates aspects of traumatic brain injury (TBI) as a method to better understand what physically happens to the brain. Researchers use a variety of models for this process, with different models able to replicate certain aspects of TBI while also producing their own limitations. An estimated 1.7 million cases of TBI occur per year, not taking into account the lasting affects that TBI may cause. TBI is also reported as a contributing factor in about 30% of all injury related death. Given how prevalent TBI is, preventing or minimizing its effects would benefit many people worldwide. Models bring advantages and disadvantages to TBI research. They are good at representing one observable aspect but must ignore other aspects. For example, a researcher may study blunt impacts with a neuronal cell culture model that is the depth of the cortical layer. The researcher subjects this to different impact sizes, shapes, and forces to see how cells react and what cytokines they release. This model works well for the cortical layer, but ignores deeper cell layers due to the inability to oxygenate a deeper cell culture effectively. In this experiment, the disadvantage and limitation of this model is cell depth. It gathers accurate information within the cortical layer, but ignores interactions that might occur below the cortical layer. (en)
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  • Traumatic brain injury modeling replicates aspects of traumatic brain injury (TBI) as a method to better understand what physically happens to the brain. Researchers use a variety of models for this process, with different models able to replicate certain aspects of TBI while also producing their own limitations. (en)
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  • Traumatic brain injury modeling (en)
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