About: Synaptotagmin

An Entity of Type: protein, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 17 isoforms in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, (E-Syt) membrane proteins, and MCTPs) and soluble (RIMS1 and RIMS2, UNC13D, synaptotagmin-related proteins and B/K) proteins. The family includes synaptotagmin 1, a Ca2+ sensor in the membrane of the pre-synaptic axon terminal, coded by gene SYT1.

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dbo:abstract
  • Synaptotagmine sind eine Gruppe von 17 an Zellmembranen lokalisierten Proteinen, die sich durch eine N-terminale Transmembranregion (TMR), eine variable Verbindung und zwei C-terminale C2-Domänen (C2A und C2B) auszeichnen. Es gibt mehrere C2-Domänen-tragende Proteingruppen, die mit Synaptotagminen verwandt sind, darunter Ferline, E-Syts und MCTPs, sowie RIMs, Munc13s und B/K. (de)
  • Las sinaptotagminas (SYT) son una familia de proteínas compuesta por 17 miembros caracterizados por una estructura muy conservada que consta de un dominio transmembrana N-terminal, un conector y dos dominios C-terminales sensibles al calcio: C2A y C2B.​ La sinaptotagmina más estudiada es la sinaptotagmina 1, que se encuentra en las vesículas sinápticas y participa en la transmisión sináptica mediante la detección de iones de calcio intracelular. (es)
  • Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 17 isoforms in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, (E-Syt) membrane proteins, and MCTPs) and soluble (RIMS1 and RIMS2, UNC13D, synaptotagmin-related proteins and B/K) proteins. The family includes synaptotagmin 1, a Ca2+ sensor in the membrane of the pre-synaptic axon terminal, coded by gene SYT1. (en)
  • Synaptotagminas são um grupo de 15 proteínas de membrana caracterizadas por uma região N-terminal transmembranar (do inglês, TMR), uma região variábel e domínios C2 C-terminais (C2A e C2B). Há outros grupos de proteínas (nominalmente Ferline, E-Syts, MCTPs, RIMs, Munc13s e B/K) que possuem domínios C2, sendo esses aparentados com as sinaptotagminas. (pt)
  • Синаптотагмін (англ. synaptotagmin) - трансмембранний кальцій-зв'язуючий білок, який відіграє важливу роль у внутрішньоклітинному мембранному транспорті. (uk)
  • Синаптотагмин (англ. synaptotagmin) — трансмембранный кальций-связывающий белок, участвующий во внутриклеточном транспорте мембран. (ru)
dbo:symbol
  • SYT
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  • 5189779 (xsd:integer)
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  • 18288 (xsd:nonNegativeInteger)
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  • 1045533105 (xsd:integer)
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dbp:caption
  • Molecular machinery driving exocytosis in neurotransmitter release: the core SNARE complex and the Ca2+ sensor synaptotagmin. (en)
dbp:membranomeSuperfamily
  • 199 (xsd:integer)
dbp:name
  • Synaptotagmin (en)
dbp:opmFamily
  • 45 (xsd:integer)
dbp:opmProtein
  • 3 (xsd:integer)
dbp:symbol
  • SYT (en)
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rdfs:comment
  • Synaptotagmine sind eine Gruppe von 17 an Zellmembranen lokalisierten Proteinen, die sich durch eine N-terminale Transmembranregion (TMR), eine variable Verbindung und zwei C-terminale C2-Domänen (C2A und C2B) auszeichnen. Es gibt mehrere C2-Domänen-tragende Proteingruppen, die mit Synaptotagminen verwandt sind, darunter Ferline, E-Syts und MCTPs, sowie RIMs, Munc13s und B/K. (de)
  • Las sinaptotagminas (SYT) son una familia de proteínas compuesta por 17 miembros caracterizados por una estructura muy conservada que consta de un dominio transmembrana N-terminal, un conector y dos dominios C-terminales sensibles al calcio: C2A y C2B.​ La sinaptotagmina más estudiada es la sinaptotagmina 1, que se encuentra en las vesículas sinápticas y participa en la transmisión sináptica mediante la detección de iones de calcio intracelular. (es)
  • Synaptotagmins (SYTs) constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 17 isoforms in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, (E-Syt) membrane proteins, and MCTPs) and soluble (RIMS1 and RIMS2, UNC13D, synaptotagmin-related proteins and B/K) proteins. The family includes synaptotagmin 1, a Ca2+ sensor in the membrane of the pre-synaptic axon terminal, coded by gene SYT1. (en)
  • Synaptotagminas são um grupo de 15 proteínas de membrana caracterizadas por uma região N-terminal transmembranar (do inglês, TMR), uma região variábel e domínios C2 C-terminais (C2A e C2B). Há outros grupos de proteínas (nominalmente Ferline, E-Syts, MCTPs, RIMs, Munc13s e B/K) que possuem domínios C2, sendo esses aparentados com as sinaptotagminas. (pt)
  • Синаптотагмін (англ. synaptotagmin) - трансмембранний кальцій-зв'язуючий білок, який відіграє важливу роль у внутрішньоклітинному мембранному транспорті. (uk)
  • Синаптотагмин (англ. synaptotagmin) — трансмембранный кальций-связывающий белок, участвующий во внутриклеточном транспорте мембран. (ru)
rdfs:label
  • Synaptotagmine (de)
  • Sinaptotagmina (es)
  • Sinaptotagmina (pt)
  • Synaptotagmin (en)
  • Синаптотагмин (ru)
  • Синаптотагмін (uk)
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