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The replication factor C, or RFC, is a five-subunit protein complex that is required for DNA replication. The subunits of this heteropentamer are named Rfc1, Rfc2, Rfc3, Rfc4, and Rfc5 in Saccharomyces cerevisiae. RFC is used in eukaryotic replication as a clamp loader, similar to the γ Complex in Escherichia coli. Its role as a clamp loader involves catalyzing the loading of PCNA onto DNA. It binds to the 3' end of the DNA and uses ATP to open the ring of PCNA so that it can encircle the DNA. ATP hydrolysis causes the release of RFC, with concomitant clamp loading onto DNA. For DNA polymerase, RFC serves as primer identification. RFC plays an important role in the proliferation, invasion, and progression of various malignant tumors. RFC acts as a tumor suppressor gene.

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  • Le facteur de réplication C (Noté RF-C pour Replication Factor-C) est une protéine ayant un rôle primordial lors de la réplication, en recrutant la protéine PCNA (Proliferative Cell Nuclear Antigen), permettant ainsi le remplacement de l'ADN polymérase α primase par l'ADN polymérase δ. (fr)
  • The replication factor C, or RFC, is a five-subunit protein complex that is required for DNA replication. The subunits of this heteropentamer are named Rfc1, Rfc2, Rfc3, Rfc4, and Rfc5 in Saccharomyces cerevisiae. RFC is used in eukaryotic replication as a clamp loader, similar to the γ Complex in Escherichia coli. Its role as a clamp loader involves catalyzing the loading of PCNA onto DNA. It binds to the 3' end of the DNA and uses ATP to open the ring of PCNA so that it can encircle the DNA. ATP hydrolysis causes the release of RFC, with concomitant clamp loading onto DNA. For DNA polymerase, RFC serves as primer identification. RFC plays an important role in the proliferation, invasion, and progression of various malignant tumors. RFC acts as a tumor suppressor gene. (en)
  • Replikationsfaktor C eller RFC är ett proteinkomplex som är nödvändigt vid eukaryot DNA-replikation. Dess uppgift är att katalysera laddningen av PCNA till DNA-molekylen. Denna egenskap gör RFC till en clamp-loader. Dess motsvarighet hos bakterier är . Denna biokemi-relaterade artikel saknar väsentlig information. Du kan hjälpa till genom att lägga till den. Den här artikeln är helt eller delvis baserad på material från engelskspråkiga Wikipedia. (sv)
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  • Le facteur de réplication C (Noté RF-C pour Replication Factor-C) est une protéine ayant un rôle primordial lors de la réplication, en recrutant la protéine PCNA (Proliferative Cell Nuclear Antigen), permettant ainsi le remplacement de l'ADN polymérase α primase par l'ADN polymérase δ. (fr)
  • The replication factor C, or RFC, is a five-subunit protein complex that is required for DNA replication. The subunits of this heteropentamer are named Rfc1, Rfc2, Rfc3, Rfc4, and Rfc5 in Saccharomyces cerevisiae. RFC is used in eukaryotic replication as a clamp loader, similar to the γ Complex in Escherichia coli. Its role as a clamp loader involves catalyzing the loading of PCNA onto DNA. It binds to the 3' end of the DNA and uses ATP to open the ring of PCNA so that it can encircle the DNA. ATP hydrolysis causes the release of RFC, with concomitant clamp loading onto DNA. For DNA polymerase, RFC serves as primer identification. RFC plays an important role in the proliferation, invasion, and progression of various malignant tumors. RFC acts as a tumor suppressor gene. (en)
  • Replikationsfaktor C eller RFC är ett proteinkomplex som är nödvändigt vid eukaryot DNA-replikation. Dess uppgift är att katalysera laddningen av PCNA till DNA-molekylen. Denna egenskap gör RFC till en clamp-loader. Dess motsvarighet hos bakterier är . Denna biokemi-relaterade artikel saknar väsentlig information. Du kan hjälpa till genom att lägga till den. Den här artikeln är helt eller delvis baserad på material från engelskspråkiga Wikipedia. (sv)
rdfs:label
  • Facteur de réplication C (fr)
  • Replication factor C (en)
  • Replikationsfaktor C (sv)
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