Quinolidomicin A1 is a 60-membered macrocyclic compound isolated from Micromonospora sp. JY16. are a class of macrolides that contain a benzoquinone chromophore as well as an immense lactone ring, which far surpasses that in . It is currently the largest identified macrolide of terrestrial origin. It was initially discovered when in a screening for anti-tumor antibiotics, where it was found to be cytotoxic against P388 murine leukemia cells (IC50 8 nM), and has later been found to have strong cytotoxic activity against HT-29, MKN28, K562, and KB.
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