About: Progabide

Property	Value
dbo:abstract	Progabide (INN; trade name Gabrene, Sanofi-Aventis) is an analogue and prodrug of γ-aminobutyric acid (GABA) used in the treatment of epilepsy. Via conversion into GABA, progabide behaves as an agonist of the GABAA, GABAB, and GABAA-ρ receptors. (en) Il progabide è una sostanza agonista altamente specifico del recettore per il GABA. L'agonismo si manifesta sia sui recettori GABAA che sui recettori GABAB. Si tratta di un profarmaco dell'acido gamma amino butirrico ed è dotato di attività antiepilettica ma non ha alcun effetto sulle funzioni neuroendocrine, al di fuori di un antagonismo verso l'aumento di prolattina indotto da neurolettici. Il farmaco sembra privo di effetto negativo sulla memoria e sull'attività psicomotoria. (it)
dbo:bioavailability	60.000000 (xsd:float)
dbo:casNumber	62666-20-0
dbo:chEMBL	287631
dbo:drugbank	DB00837
dbo:fdaUniiCode	38C836J57Z
dbo:pubchem	5361323
dbo:thumbnail	wiki-commons:Special:FilePath/Progabide_structure.svg?width=300
dbo:wikiPageID	2477960 (xsd:integer)
dbo:wikiPageLength	6528 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1124411343 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Psychosis dbr:Schizophrenia dbr:Epilepsy dbr:Anxiety_disorder dbr:Renal dbr:Γ-aminobutyric_acid dbc:Chlorobenzenes dbc:Fluoroarenes dbc:GABAA-rho_receptor_agonists dbc:GABAB_receptor_agonists dbc:GABA_analogues dbc:Imines dbc:Phenols dbr:Clinical_depression dbr:Prodrug dbr:Active_metabolite dbr:Tolgabide dbr:GABAA-rho_receptor dbr:GABAA_receptor dbr:Agonist dbr:France dbc:GABAA_receptor_agonists dbr:Parkinson's_disease dbc:Anticonvulsants dbr:Haloperidol dbr:Hepatic dbr:International_Nonproprietary_Name dbr:Tardive_dyskinesia dbr:Spasticity dbr:Catalepsy dbr:Lennox-Gastaut_syndrome dbr:Sanofi-Aventis dbr:Analog_(chemistry) dbr:GABA_B_receptor dbr:Progabide_acid dbr:File:Progabide_synthesis.png
dbp:atcPrefix	N03 (en)
dbp:atcSuffix	AG05 (en)
dbp:bioavailability	60.0
dbp:c	17 (xsd:integer)
dbp:casNumber	62666 (xsd:integer)
dbp:chembl	287631 (xsd:integer)
dbp:chemspiderid	10442693 (xsd:integer)
dbp:cl	1 (xsd:integer)
dbp:drugbank	DB00837 (en)
dbp:eliminationHalfLife	14400.0
dbp:excretion	dbr:Renal
dbp:f	1 (xsd:integer)
dbp:h	16 (xsd:integer)
dbp:iupacName	4 (xsd:integer)
dbp:legalStatus	Prescription only (en)
dbp:metabolism	dbr:Hepatic
dbp:n	2 (xsd:integer)
dbp:o	2 (xsd:integer)
dbp:proteinBound	95.0
dbp:pubchem	5361323 (xsd:integer)
dbp:routesOfAdministration	Oral (en)
dbp:smiles	Clc1ccc/Cc2ccccc2O (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	IBALRBWGSVJPAP-HEHNFIMWSA-N (en)
dbp:unii	38 (xsd:integer)
dbp:verifiedrevid	464215284 (xsd:integer)
dbp:watchedfields	changed (en)
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:GABAergics dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Cite_patent dbt:Anticonvulsants
dcterms:subject	dbc:Chlorobenzenes dbc:Fluoroarenes dbc:GABAA-rho_receptor_agonists dbc:GABAB_receptor_agonists dbc:GABA_analogues dbc:Imines dbc:Phenols dbc:GABAA_receptor_agonists dbc:Anticonvulsants
gold:hypernym	dbr:Analogue
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Statement106722453 yago:Substance100019613 yago:WikicatPhenols
rdfs:comment	Progabide (INN; trade name Gabrene, Sanofi-Aventis) is an analogue and prodrug of γ-aminobutyric acid (GABA) used in the treatment of epilepsy. Via conversion into GABA, progabide behaves as an agonist of the GABAA, GABAB, and GABAA-ρ receptors. (en) Il progabide è una sostanza agonista altamente specifico del recettore per il GABA. L'agonismo si manifesta sia sui recettori GABAA che sui recettori GABAB. Si tratta di un profarmaco dell'acido gamma amino butirrico ed è dotato di attività antiepilettica ma non ha alcun effetto sulle funzioni neuroendocrine, al di fuori di un antagonismo verso l'aumento di prolattina indotto da neurolettici. Il farmaco sembra privo di effetto negativo sulla memoria e sull'attività psicomotoria. (it)
rdfs:label	Progabide (it) Progabide (en)
owl:sameAs	freebase:Progabide http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00837 yago-res:Progabide wikidata:Progabide dbpedia-it:Progabide dbpedia-sh:Progabide dbpedia-sr:Progabide https://global.dbpedia.org/id/3x1wC
prov:wasDerivedFrom	wikipedia-en:Progabide?oldid=1124411343&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Progabide_structure.svg wiki-commons:Special:FilePath/Progabide_synthesis.png
foaf:isPrimaryTopicOf	wikipedia-en:Progabide
is dbo:wikiPageRedirects of	dbr:Gabren dbr:C17H16ClFN2O2 dbr:ATC_code_N03AG05 dbr:ATCvet_code_QN03AG05
is dbo:wikiPageWikiLink of	dbr:Anticonvulsant dbr:Γ-Aminobutyric_acid dbr:Gabren dbr:SL-75102 dbr:C17H16ClFN2O2 dbr:Tolgabide dbr:GABAA_receptor dbr:GABA_analogue dbr:GABA_receptor_agonist dbr:Fengabine dbr:ATC_code_N03AG05 dbr:ATCvet_code_QN03AG05 dbr:Tardive_dyskinesia dbr:ATC_code_N03 dbr:List_of_drugs:_Pro–Prz
is foaf:primaryTopic of	wikipedia-en:Progabide