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- A predictive adaptive response (PAR) is a developmental trajectory taken by an organism during a period of developmental plasticity in response to perceived environmental cues. This PAR does not confer an immediate advantage to the developing organism; however, if the PAR correctly anticipates the postnatal environment it will be advantageous in later life, if the environment the organism is born into differs from that anticipated by the PAR it will result in a mismatch. PAR mechanisms were first recognized in research done on human fetuses that investigated whether poor nutrition results in the inevitable diagnosis of Type 2 diabetes in later life. PARs are thought to occur through epigenetic mechanisms that alter gene expression, such as DNA methylation and histone modification, and do not involve changes to the DNA sequence of the developing organism. Examples of PARs include greater helmet development in Daphnia cucullata in response to maternal exposure to predator pheromones, rats exposed to glucocorticoid during late gestation led to an intolerance to glucose as adults, and coat thickness determination in vole pups by the photoperiod length experienced by the mother. Two hypotheses to explain PAR are the "thrifty phenotype" hypothesis and the developmental plasticity hypothesis. (en)
- 预知适应性反应（Predictive adaptive response）是指胎儿受到外界环境刺激后，对宫外环境进行预测，从而改变自身发育轨迹以适应环境变化的过程。预知适应性反应这一概念源自进化生物学。机体在受到环境干扰时，可做出两种适应性反应：即刻适应性反应（Immediately adaptive responses, IAPs）和预知适应性反应（predictive adaptive responses, PARs）, 已成为胎儿选择发育表型的基础。 (zh)
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- 9801 (xsd:nonNegativeInteger)
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- 预知适应性反应（Predictive adaptive response）是指胎儿受到外界环境刺激后，对宫外环境进行预测，从而改变自身发育轨迹以适应环境变化的过程。预知适应性反应这一概念源自进化生物学。机体在受到环境干扰时，可做出两种适应性反应：即刻适应性反应（Immediately adaptive responses, IAPs）和预知适应性反应（predictive adaptive responses, PARs）, 已成为胎儿选择发育表型的基础。 (zh)
- A predictive adaptive response (PAR) is a developmental trajectory taken by an organism during a period of developmental plasticity in response to perceived environmental cues. This PAR does not confer an immediate advantage to the developing organism; however, if the PAR correctly anticipates the postnatal environment it will be advantageous in later life, if the environment the organism is born into differs from that anticipated by the PAR it will result in a mismatch. PAR mechanisms were first recognized in research done on human fetuses that investigated whether poor nutrition results in the inevitable diagnosis of Type 2 diabetes in later life. PARs are thought to occur through epigenetic mechanisms that alter gene expression, such as DNA methylation and histone modification, and do n (en)
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- Predictive adaptive response (en)
- 预知适应性反应 (zh)
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