About: OrthoDB

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OrthoDB presents a catalog of orthologous protein-coding genes across vertebrates, arthropods, fungi, plants, and bacteria. Orthology refers to the last common ancestor of the species under consideration, and thus OrthoDB explicitly delineates orthologs at each major radiation along the species phylogeny. The database of orthologs presents available protein descriptors, together with Gene Ontology and InterPro attributes, which serve to provide general descriptive annotations of the orthologous groups, and facilitate comprehensive orthology database querying. OrthoDB also provides computed evolutionary traits of orthologs, such as gene duplicability and loss profiles, divergence rates, sibling groups, and gene intron-exon architectures.

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dbo:abstract
  • OrthoDB est un catalogue de gènes codant des protéines orthologues à travers les vertébrés, les arthropodes, les fungi, et les bactéries. L'orthologie fait référence au dernier ancêtre commun d'un ensemble d'espèces considérées, et donc OrthoDB définie explicitement les orthologues à chaque point de rayonnement le long de la phylogénie des espèces. La base de données OrthoDB fourni des descripteurs de protéines, ainsi que les attributs GO et InterPro, qui servent à fournir des annotations descriptives générales des groupes orthologues et faciliter l'interrogation de base de données de orthologie. OrthoDB fournit également des traits évolutifs d'orthologues calculés, comme les duplications et les profils de perte, les taux de divergence, et des familles, qui sont maintenant étendus pour inclure les détails d'architecture d'intron-exon, orthologues de synténie, et les arbres parent-enfant. (fr)
  • OrthoDB presents a catalog of orthologous protein-coding genes across vertebrates, arthropods, fungi, plants, and bacteria. Orthology refers to the last common ancestor of the species under consideration, and thus OrthoDB explicitly delineates orthologs at each major radiation along the species phylogeny. The database of orthologs presents available protein descriptors, together with Gene Ontology and InterPro attributes, which serve to provide general descriptive annotations of the orthologous groups, and facilitate comprehensive orthology database querying. OrthoDB also provides computed evolutionary traits of orthologs, such as gene duplicability and loss profiles, divergence rates, sibling groups, and gene intron-exon architectures. In comparative genomics, the importance of scale cannot be underestimated. As gene orthology delineation requires specific expertise and considerable computational resources, scale is something that individual non-specialist research groups cannot accomplish on their own. This challenging task is achieved by OrthoDB, with very comprehensive sets of species and several unique features such as the extensive functional and evolutionary annotations of orthologous groups, with the integration of many useful links to other world-leading databases that focus on capturing information about gene function. No genome can exist as a useful data source without extensive comparative analyses with other genomes – OrthoDB provides a critically important resource for comparative genomics for the entire community of researchers from those interested in grand evolutionary questions to those focused on the specific biological functions of individual genes. (en)
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dbo:title
  • OrthoDB (en)
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  • 31367370 (xsd:integer)
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  • 13423 (xsd:nonNegativeInteger)
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  • 1091105494 (xsd:integer)
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dbp:author
  • Evgenia V. Kriventseva (en)
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dbp:citation
  • Kriventseva et al. (en)
dbp:description
  • Catalog of Orthologs. (en)
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dbp:laboratory
  • Computational Evolutionary Genomics Group (en)
dbp:license
dbp:logo
  • 150 (xsd:integer)
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  • 2007 (xsd:integer)
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dbp:title
  • OrthoDB (en)
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dc:description
  • Catalog ofOrthologs.
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rdfs:comment
  • OrthoDB est un catalogue de gènes codant des protéines orthologues à travers les vertébrés, les arthropodes, les fungi, et les bactéries. L'orthologie fait référence au dernier ancêtre commun d'un ensemble d'espèces considérées, et donc OrthoDB définie explicitement les orthologues à chaque point de rayonnement le long de la phylogénie des espèces. La base de données OrthoDB fourni des descripteurs de protéines, ainsi que les attributs GO et InterPro, qui servent à fournir des annotations descriptives générales des groupes orthologues et faciliter l'interrogation de base de données de orthologie. OrthoDB fournit également des traits évolutifs d'orthologues calculés, comme les duplications et les profils de perte, les taux de divergence, et des familles, qui sont maintenant étendus pour inc (fr)
  • OrthoDB presents a catalog of orthologous protein-coding genes across vertebrates, arthropods, fungi, plants, and bacteria. Orthology refers to the last common ancestor of the species under consideration, and thus OrthoDB explicitly delineates orthologs at each major radiation along the species phylogeny. The database of orthologs presents available protein descriptors, together with Gene Ontology and InterPro attributes, which serve to provide general descriptive annotations of the orthologous groups, and facilitate comprehensive orthology database querying. OrthoDB also provides computed evolutionary traits of orthologs, such as gene duplicability and loss profiles, divergence rates, sibling groups, and gene intron-exon architectures. (en)
rdfs:label
  • OrthoDB (fr)
  • OrthoDB (en)
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