Nicholas Alexios Alexis (1761-1818) was a key figure and a resistance leader in the independence struggle in Crete. He was born in Marmaketo, a village of Lassithi Plateau, in 1761 when Crete was part of the Ottoman Empire. He was a son of Alexios Alexis (1692-1786) and a grandson of the nobleman Misser Alexis (1637- ? ).