About: Metaxalone

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Metaxalone, sold under the brand name Skelaxin, is a muscle relaxant medication used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is a moderately strong muscle relaxant, with relatively low incidence of side effects. Common side effects include nausea, vomiting, drowsiness, and central nervous system (CNS) side effects, such as dizziness, headache, and irritability.

Property	Value
dbo:abstract	Metaxalone, sold under the brand name Skelaxin, is a muscle relaxant medication used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is a moderately strong muscle relaxant, with relatively low incidence of side effects. Common side effects include nausea, vomiting, drowsiness, and central nervous system (CNS) side effects, such as dizziness, headache, and irritability. The metabolism of metaxalone involves enzymes CYP1A2 and CYP2C19 in the cytochrome P450 system. Because many medications are metabolized by enzymes in this system, precaution must be taken when administering it with other medications involving the P450 system to avoid interactions. Because of the potential for side effects, this drug is considered a high risk in the elderly. (en)
dbo:alternativeName	Skelaxin (en)
dbo:casNumber	1665-48-1
dbo:chEMBL	1079604
dbo:drugbank	DB00660
dbo:fdaUniiCode	1NMA9J598Y
dbo:kegg	D00773
dbo:medlinePlus	a682010
dbo:pubchem	15459
dbo:thumbnail	wiki-commons:Special:FilePath/Metaxalone.svg?width=300
dbo:wikiPageExternalLink	https://druginfo.nlm.nih.gov/drugportal/name/metaxalone
dbo:wikiPageID	3127074 (xsd:integer)
dbo:wikiPageLength	6916 (xsd:nonNegativeInteger)
dbo:wikiPageRevisionID	1087395499 (xsd:integer)
dbo:wikiPageWikiLink	dbr:Cytochrome_P450 dbr:Depressant dbc:Carbamates dbc:Muscle_relaxants dbc:Pfizer_brands dbc:Phenol_ethers dbr:Oral_administration dbr:Liver dbc:Oxazolidines dbr:Muscle_relaxant dbr:Central_nervous_system dbc:Drugs_with_unknown_mechanisms_of_action dbr:Kidney dbr:Bioavailability dbr:CYP1A2 dbr:CYP2B6 dbr:CYP2C19 dbr:CYP2C9 dbr:CYP2D6 dbr:CYP2E1 dbr:CYP3A dbr:CYP3A4 dbr:Metolazone dbr:Sprain
dbp:atcPrefix	None (en)
dbp:bioavailability	Unknown (en)
dbp:c	12 (xsd:integer)
dbp:casNumber	1665 (xsd:integer)
dbp:chembl	1079604 (xsd:integer)
dbp:chemspiderid	14709 (xsd:integer)
dbp:dailymedid	Metaxalone (en)
dbp:drugbank	DB00660 (en)
dbp:eliminationHalfLife	33120.0
dbp:excretion	dbr:Kidney
dbp:h	15 (xsd:integer)
dbp:iupacName	5 (xsd:integer)
dbp:iupharLigand	7609 (xsd:integer)
dbp:kegg	D00773 (en)
dbp:legalUs	Rx-only (en)
dbp:medlineplus	a682010 (en)
dbp:metabolism	dbr:Liver
dbp:n	1 (xsd:integer)
dbp:o	3 (xsd:integer)
dbp:pregnancyUs	N (en)
dbp:pubchem	15459 (xsd:integer)
dbp:routesOfAdministration	dbr:Oral_administration
dbp:smiles	O=C2OCCN2 (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	IMWZZHHPURKASS-UHFFFAOYSA-N (en)
dbp:tradename	Skelaxin (en)
dbp:unii	1 (xsd:integer)
dbp:verifiedrevid	458442143 (xsd:integer)
dbp:width	200 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Cite_web dbt:Cn dbt:Distinguish dbt:Drugbox dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Muscle_relaxants dbt:Drugs.com dbt:Medcn
dcterms:subject	dbc:Carbamates dbc:Muscle_relaxants dbc:Pfizer_brands dbc:Phenol_ethers dbc:Oxazolidines dbc:Drugs_with_unknown_mechanisms_of_action
gold:hypernym	dbr:Relaxant
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatCarbamates yago:Abstraction100002137 yago:Carbamate114792281 yago:Chemical114806838 yago:Compound114818238 yago:Element114840755 yago:Material114580897 yago:Matter100020827 yago:Part113809207 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 dbo:Drug yago:Salt115010703 yago:Substance100019613 yago:WikicatPhenolEthers umbel-rc:DrugProduct
rdfs:comment	Metaxalone, sold under the brand name Skelaxin, is a muscle relaxant medication used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is a moderately strong muscle relaxant, with relatively low incidence of side effects. Common side effects include nausea, vomiting, drowsiness, and central nervous system (CNS) side effects, such as dizziness, headache, and irritability. (en)
rdfs:label	Metaxalone (en)
owl:sameAs	freebase:Metaxalone yago-res:Metaxalone http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00660 wikidata:Metaxalone dbpedia-cy:Metaxalone dbpedia-sh:Metaxalone dbpedia-sr:Metaxalone dbpedia-vi:Metaxalone https://global.dbpedia.org/id/4rfZR
prov:wasDerivedFrom	wikipedia-en:Metaxalone?oldid=1087395499&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Metaxalone.svg
foaf:isPrimaryTopicOf	wikipedia-en:Metaxalone
is dbo:wikiPageRedirects of	dbr:Skelaxin dbr:Zorane dbr:Skelxain
is dbo:wikiPageWikiLink of	dbr:List_of_compounds_with_carbon_number_12 dbr:Antispasmodic dbr:C12H15NO3 dbr:Muscle_relaxant dbr:Chlorzoxazone dbr:Skelaxin dbr:Zorane dbr:Mephenoxalone dbr:Methocarbamol dbr:Metolazone dbr:Sedative dbr:King_Pharmaceuticals dbr:Serotonin_syndrome dbr:List_of_drugs:_Met dbr:Skelxain
is foaf:primaryTopic of	wikipedia-en:Metaxalone