| dbo:abstract
|
- LFA-1 (z anglického lymphocyte function-associated antigen 1) je membránový receptor nacházející se na povrchu bílých krvinek. Řadí se do rodiny adhezivních receptorů, tzv. integrinů. (cs)
- Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which is the process by which leukocytes leave the bloodstream to enter the tissues. LFA-1 also mediates firm arrest of leukocytes. Additionally, LFA-1 is involved in the process of cytotoxic T cell mediated killing as well as antibody mediated killing by granulocytes and monocytes. As of 2007, LFA-1 has 6 known ligands: ICAM-1, ICAM-2, ICAM-3, ICAM-4, ICAM-5, and JAM-A. LFA-1/ICAM-1 interactions have recently been shown to stimulate signaling pathways that influence T cell differentiation. LFA-1 belongs to the integrin superfamily of adhesion molecules. (en)
- La LFA-1 est une molécule d'adhérence de la famille des Intégrine présente notamment à la surface des leucocytes. (fr)
- LFA-1 (интегрин αLβ2; англ. Lymphocyte function-associated antigen 1) — мембранный белок, гетеродимерный интегрин подсемейства β2-интегринов, состоящий из альфа цепи αL и бета цепи β2. Рецептор ICAM-1, играет важную роль в рекрутировании лейкоцитов к участку воспаления. (ru)
- 淋巴球功能性抗原1（英文：Lymphocyte function-associated antigen 1, LFA-1）是淋巴球上的細胞黏附分子，屬於黏附分子中整合素（integrin）超家族。 LFA-1對淋巴球的遷移很重要，能幫助淋巴球離開血流並進入組織。LFA-1亦能幫忙減緩中性球的流速好讓表皮細胞能抓住他們。 此外，LFA-1也參與细胞毒性T细胞的胞殺過程、粒细胞與单核细胞的抗體調節胞殺作用。自2007年起，已經發現了LFA-1的6個配體：、、ICAM-3、ICAM-4、ICAM-5和JAM-A 。最近顯示LFA-1與ICAM-1的互動能刺激T細胞分化的傳訊途徑。 (zh)
|
| dbo:wikiPageExternalLink
| |
| dbo:wikiPageID
| |
| dbo:wikiPageLength
|
- 7858 (xsd:nonNegativeInteger)
|
| dbo:wikiPageRevisionID
| |
| dbo:wikiPageWikiLink
| |
| dbp:wikiPageUsesTemplate
| |
| dcterms:subject
| |
| rdfs:comment
|
- LFA-1 (z anglického lymphocyte function-associated antigen 1) je membránový receptor nacházející se na povrchu bílých krvinek. Řadí se do rodiny adhezivních receptorů, tzv. integrinů. (cs)
- Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which is the process by which leukocytes leave the bloodstream to enter the tissues. LFA-1 also mediates firm arrest of leukocytes. Additionally, LFA-1 is involved in the process of cytotoxic T cell mediated killing as well as antibody mediated killing by granulocytes and monocytes. As of 2007, LFA-1 has 6 known ligands: ICAM-1, ICAM-2, ICAM-3, ICAM-4, ICAM-5, and JAM-A. LFA-1/ICAM-1 interactions have recently been shown to stimulate signaling pathways that influence T cell differentiation. LFA-1 belongs to the integrin superfamily of adhesion molecules. (en)
- La LFA-1 est une molécule d'adhérence de la famille des Intégrine présente notamment à la surface des leucocytes. (fr)
- LFA-1 (интегрин αLβ2; англ. Lymphocyte function-associated antigen 1) — мембранный белок, гетеродимерный интегрин подсемейства β2-интегринов, состоящий из альфа цепи αL и бета цепи β2. Рецептор ICAM-1, играет важную роль в рекрутировании лейкоцитов к участку воспаления. (ru)
- 淋巴球功能性抗原1（英文：Lymphocyte function-associated antigen 1, LFA-1）是淋巴球上的細胞黏附分子，屬於黏附分子中整合素（integrin）超家族。 LFA-1對淋巴球的遷移很重要，能幫助淋巴球離開血流並進入組織。LFA-1亦能幫忙減緩中性球的流速好讓表皮細胞能抓住他們。 此外，LFA-1也參與细胞毒性T细胞的胞殺過程、粒细胞與单核细胞的抗體調節胞殺作用。自2007年起，已經發現了LFA-1的6個配體：、、ICAM-3、ICAM-4、ICAM-5和JAM-A 。最近顯示LFA-1與ICAM-1的互動能刺激T細胞分化的傳訊途徑。 (zh)
|
| rdfs:label
|
- LFA-1 (cs)
- LFA-1 (fr)
- Lymphocyte function-associated antigen 1 (en)
- LFA-1 (ru)
- 淋巴球功能性抗原1 (zh)
|
| owl:sameAs
| |
| prov:wasDerivedFrom
| |
| foaf:isPrimaryTopicOf
| |
| is dbo:wikiPageRedirects
of | |
| is dbo:wikiPageWikiLink
of | |
| is foaf:primaryTopic
of | |
