Issano is a village of Cuyuni-Mazaruni (Region 7), Guyana. It's located along the Mazaruni River, and is a hub for mining. In 2012, the population was 220. Issano is a mostly Amerindian community. It has a Primary school (Saint Martin's), Health Centre and airstrip (ICAO: SYIS). The main overland roadway is the Issano road, which runs 75 miles from the Bartica/Potaro road and extends approximately 52 miles to the Issano landing.
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