Hester C. Jeffrey, née Whitehurst (c. 1842 – January 2, 1934, also known as Jeffreys or Jeffries, or Mrs. R. Jerome Jeffrey, after her husband) was an African-American activist, suffragist, and community organizer in Rochester, N.Y., and New York City. She is known for her involvement with the Political Equality Club, the Women's Christian Temperance Union, and the National Association of Colored Women's Clubs.