About: Fosdagrocorat

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Fosdagrocorat (developmental code names PF-04171327 and PF-4171327; also known as dagrocorat 2-(dihydrogen phosphate)) is a nonsteroidal but steroid-like selective glucocorticoid receptor modulator (SGRM) which was under development for the treatment of rheumatoid arthritis but was never marketed. It is the C2 dihydrogen phosphate ester of dagrocorat, and acts as a prodrug of dagrocorat with improved pharmacokinetics. The drug reached phase II clinical trials prior to the discontinuation of its development.

Property	Value
dbo:abstract	Fosdagrocorat (developmental code names PF-04171327 and PF-4171327; also known as dagrocorat 2-(dihydrogen phosphate)) is a nonsteroidal but steroid-like selective glucocorticoid receptor modulator (SGRM) which was under development for the treatment of rheumatoid arthritis but was never marketed. It is the C2 dihydrogen phosphate ester of dagrocorat, and acts as a prodrug of dagrocorat with improved pharmacokinetics. The drug reached phase II clinical trials prior to the discontinuation of its development. (en)
dbo:casNumber	1044535-58-1
dbo:chEMBL	3137316
dbo:class	dbr:Selective_glucocorticoid_receptor_modulator
dbo:fdaUniiCode	HPI19004QS
dbo:kegg	D10634
dbo:pubchem	24872952
dbo:thumbnail	wiki-commons:Special:FilePath/Fosdagrocorat.svg?width=300
dbo:wikiPageExternalLink	http://adisinsight.springer.com/drugs/800029004
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dbo:wikiPageWikiLink	dbr:Hydrogen dbr:Rheumatoid_arthritis dbc:Selective_glucocorticoid_receptor_modulators dbr:Dagrocorat dbc:Glucocorticoids dbc:Phenanthrenes dbc:Phenyl_compounds dbc:Phosphate_esters dbc:Prodrugs dbc:Trifluoromethyl_compounds dbr:Ester dbr:Steroid dbr:Clinical_trial dbr:Prodrug dbr:AZD-5423 dbc:Carboxamides dbr:Nonsteroidal dbc:Pyridines dbc:Anti-inflammatory_agents dbr:Mapracorat dbr:Phosphate dbr:Selective_glucocorticoid_receptor_modulator dbr:Pharmacokinetics dbr:Phases_of_clinical_research
dbp:c	29 (xsd:integer)
dbp:casNumber	1044535 (xsd:integer)
dbp:chembl	3137316 (xsd:integer)
dbp:chemspiderid	32699790 (xsd:integer)
dbp:class	dbr:Selective_glucocorticoid_receptor_modulator
dbp:f	3 (xsd:integer)
dbp:h	30 (xsd:integer)
dbp:iupacName	[-4a-Benzyl-7-[carbamoyl]-2--1,3,4,9,10,10a-hexahydrophenanthren-2-yl] dihydrogen phosphate (en)
dbp:kegg	D10634 (en)
dbp:n	2 (xsd:integer)
dbp:o	5 (xsd:integer)
dbp:p	1 (xsd:integer)
dbp:pubchem	24872952 (xsd:integer)
dbp:smiles	CC1=CNCC2=CC3=C[C@@]4CC5=CC=CC=C5 (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	BVXLAHSJXXSWFF-KEKPKEOLSA-N (en)
dbp:synonyms	PF-04171327; PF-4171327; Dagrocorat 2-; Dagrocorat dihydrogen phosphate (en)
dbp:unii	HPI19004QS (en)
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rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	Fosdagrocorat (developmental code names PF-04171327 and PF-4171327; also known as dagrocorat 2-(dihydrogen phosphate)) is a nonsteroidal but steroid-like selective glucocorticoid receptor modulator (SGRM) which was under development for the treatment of rheumatoid arthritis but was never marketed. It is the C2 dihydrogen phosphate ester of dagrocorat, and acts as a prodrug of dagrocorat with improved pharmacokinetics. The drug reached phase II clinical trials prior to the discontinuation of its development. (en)
rdfs:label	Fosdagrocorat (en)
owl:sameAs	wikidata:Fosdagrocorat https://global.dbpedia.org/id/2Z5QQ
prov:wasDerivedFrom	wikipedia-en:Fosdagrocorat?oldid=1098347320&ns=0
foaf:depiction	wiki-commons:Special:FilePath/Fosdagrocorat.svg
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