About: Dopexamine

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Dopexamine is a synthetic analogue of dopamine that is administered intravenously in hospitals to reduce exacerbations of heart failure and to treat heart failure following cardiac surgery. It is not used often, as more established drugs like epinephrine, dopamine, dobutamine, norepinephrine, and levosimendan work as well. It works by stimulating beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopamine receptor D2. It also inhibits the neuronal re-uptake of norepinephrine. The most common adverse effects include fast heart beats and nausea.

Property	Value
dbo:abstract	Dopexamin ist eine chemische Verbindung aus der Gruppe der Katecholamine, die in der Medizin als Arzneistoff in der Behandlung von Herzinsuffizienz eingesetzt wird. Die Substanz wirkt als Beta-1- und Beta-2-Sympathomimetikum. (de) Dopexamine is a synthetic analogue of dopamine that is administered intravenously in hospitals to reduce exacerbations of heart failure and to treat heart failure following cardiac surgery. It is not used often, as more established drugs like epinephrine, dopamine, dobutamine, norepinephrine, and levosimendan work as well. It works by stimulating beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopamine receptor D2. It also inhibits the neuronal re-uptake of norepinephrine. The most common adverse effects include fast heart beats and nausea. It was discovered by scientists at Fisons, which licensed it to Ipsen in 1993, and Ipsen in turn licensed it to Élan in 1999. Ipsen licensed rights in North America and Japan to Circassia in 2008; the drug had never been approved in those countries. Dopexamine went off-patent in 2010. (en)
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rdfs:comment	Dopexamin ist eine chemische Verbindung aus der Gruppe der Katecholamine, die in der Medizin als Arzneistoff in der Behandlung von Herzinsuffizienz eingesetzt wird. Die Substanz wirkt als Beta-1- und Beta-2-Sympathomimetikum. (de) Dopexamine is a synthetic analogue of dopamine that is administered intravenously in hospitals to reduce exacerbations of heart failure and to treat heart failure following cardiac surgery. It is not used often, as more established drugs like epinephrine, dopamine, dobutamine, norepinephrine, and levosimendan work as well. It works by stimulating beta-2 adrenergic receptors and peripheral dopamine receptor D1 and dopamine receptor D2. It also inhibits the neuronal re-uptake of norepinephrine. The most common adverse effects include fast heart beats and nausea. (en)
rdfs:label	Dopexamin (de) Dopexamine (en)
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