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- Differentially methylated regions (DMRs) are genomic regions with different DNA methylation status across different biological samples and regarded as possible functional regions involved in gene transcriptional regulation. The biological samples can be different cells/tissues within the same individual, the same cell/tissue at different times, cells/tissues from different individuals, even different alleles in the same cell. DNA is mostly methylated at a CpG site, which is a cytosine followed by a guanine. The “p” refers to the phosphate linker between them. DMR usually involves adjacent sites or a group of sites close together that have different methylation patterns between samples. CpG islands appear to be unmethylated in most of the normal tissues, however, are highly methylated in cancer tissues. There are several different types of DMRs. These include tissue-specific DMR (tDMR), cancer-specific DMR (cDMR), development stages (dDMRs), reprogramming-specific DMR (rDMR), allele-specific DMR (AMR), and aging-specific DMR (aDMR). DNA methylation is associated with cell differentiation and proliferation. (en)
- 差异甲基化区（英語：Differentially methylated regions，DMRs）指在多种样本（组织、细胞、个体等）中基因组里甲基化状态不相同的区域，被看作为可能参与基因转录水平调控的功能性区域。在多种组织中鉴定DMRs（T-DMRs）综合考察了人类组织中表观遗传学的差异。癌症与正常样品间的DMRs（C-DMRs）展示出癌症中甲基化缺失情况。众所周知，DNA甲基化与细胞分化及增殖有关，现找到发育阶段（D-DMRs）及重编程阶段（R-DMRs）中存在的许多DMRs。此外还存在着个体内DMRs（Intra-DMRs），这种DMRs在给定的个体中随着年龄的增长而在全局DNA甲基化过程中发生纵向改变。也有个体间DMRs（Inter-DMRs），这种DMRs在不同个体间存在差异甲基化类型。 (zh)
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- 差异甲基化区（英語：Differentially methylated regions，DMRs）指在多种样本（组织、细胞、个体等）中基因组里甲基化状态不相同的区域，被看作为可能参与基因转录水平调控的功能性区域。在多种组织中鉴定DMRs（T-DMRs）综合考察了人类组织中表观遗传学的差异。癌症与正常样品间的DMRs（C-DMRs）展示出癌症中甲基化缺失情况。众所周知，DNA甲基化与细胞分化及增殖有关，现找到发育阶段（D-DMRs）及重编程阶段（R-DMRs）中存在的许多DMRs。此外还存在着个体内DMRs（Intra-DMRs），这种DMRs在给定的个体中随着年龄的增长而在全局DNA甲基化过程中发生纵向改变。也有个体间DMRs（Inter-DMRs），这种DMRs在不同个体间存在差异甲基化类型。 (zh)
- Differentially methylated regions (DMRs) are genomic regions with different DNA methylation status across different biological samples and regarded as possible functional regions involved in gene transcriptional regulation. The biological samples can be different cells/tissues within the same individual, the same cell/tissue at different times, cells/tissues from different individuals, even different alleles in the same cell. (en)
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- Differentially methylated region (en)
- 差异甲基化区 (zh)
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