About: Apararenone

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

Apararenone (INN) (developmental code name MT-3995) is a nonsteroidal antimineralocorticoid which is under development by Mitsubishi Tanabe Pharma for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis. It was also previously being developed for the treatment of hypertension, but development was discontinued for this indication. Apararenone acts as a highly selective antagonist of the mineralocorticoid receptor (Ki < 50 nM), the receptor for aldosterone. As of 2017, it is in phase II clinical trials.

Property	Value
dbo:abstract	Apararenone (INN) (developmental code name MT-3995) is a nonsteroidal antimineralocorticoid which is under development by Mitsubishi Tanabe Pharma for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis. It was also previously being developed for the treatment of hypertension, but development was discontinued for this indication. Apararenone acts as a highly selective antagonist of the mineralocorticoid receptor (Ki < 50 nM), the receptor for aldosterone. As of 2017, it is in phase II clinical trials. (en)
dbo:casNumber	945966-46-1
dbo:chEMBL	2181929
dbo:class	dbr:Antimineralocorticoid
dbo:fdaUniiCode	832663U2NB
dbo:pubchem	24744336
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dbo:wikiPageExternalLink	http://adisinsight.springer.com/drugs/800032686
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dbp:c	17 (xsd:integer)
dbp:casNumber	945966 (xsd:integer)
dbp:chembl	2181929 (xsd:integer)
dbp:chemspiderid	28663572 (xsd:integer)
dbp:class	dbr:Antimineralocorticoid
dbp:f	1 (xsd:integer)
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dbp:iupacName	N-[4--2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide (en)
dbp:n	2 (xsd:integer)
dbp:o	4 (xsd:integer)
dbp:pubchem	24744336 (xsd:integer)
dbp:routesOfAdministration	dbr:Oral_administration
dbp:s	1 (xsd:integer)
dbp:smiles	CC1C (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	AZNHWXAFPBYFGH-UHFFFAOYSA-N (en)
dbp:synonyms	MT-3995 (en)
dbp:unii	832663 (xsd:integer)
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rdfs:comment	Apararenone (INN) (developmental code name MT-3995) is a nonsteroidal antimineralocorticoid which is under development by Mitsubishi Tanabe Pharma for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis. It was also previously being developed for the treatment of hypertension, but development was discontinued for this indication. Apararenone acts as a highly selective antagonist of the mineralocorticoid receptor (Ki < 50 nM), the receptor for aldosterone. As of 2017, it is in phase II clinical trials. (en)
rdfs:label	Apararenone (en)
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foaf:depiction	wiki-commons:Special:FilePath/Apararenone.svg
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