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- Amentoflavone is a biflavonoid (bis-apigenin coupled at 8 and 3' positions, or 3′,8′′-biapigenin) constituent of a number of plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Hypericum perforatum (St. John's Wort) and Xerophyta plicata. Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body. It is also an inhibitor of human cathepsin B. Amentoflavone has a variety of in vitro activities including antimalarial activity, anticancer activity (which may, at least in part, be mediated by its inhibition of fatty acid synthase), and antagonist activity at the κ-opioid receptor (Ke = 490 nmol L−1) as well as activity at the allosteric benzodiazepine site of the GABAA receptor as a negative allosteric modulator. (en)
- Amentoflavona es un biflavonoide (bis-apigenina) constitutivo de un número de plantas, incluyendo Ginkgo biloba, Chamaecyparis obtusa, Hypericum perforatum) y Xerophyta plicata. Amentoflavona puede interactuar con muchos medicamentos por ser un potente inhibidor de CYP3A4 y CYP2C9, que son las enzimas responsables del metabolismo de algunos fármacos en el organismo. También es un inhibidor de la catepsina B humana. Amentoflavona tiene una variedad de actividades in vitro, incluyendo actividad antimalárica, actividad contra el cáncer (que puede, al menos en parte, ser mediada por su inhibición de la sintasa de ácidos grasos ), y afinidades por los receptores opioides (como un antagonista) y por el sitio alostérico (benzodiazepina) en el como modulador alostérico negativo. (es)
- L'amentoflavone è un flavone presente in numerose piante tra cui Ginkgo biloba, Chamaecyparis obtusa, Hypericum perforatum e Xerophyta plicata. (it)
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- Didemethyl-ginkgetin (en)
- 3′,8′′-Biapigenin (en)
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- (4′,5,7-Trihydroxyflavone)-(3′→8)-(4′,5,7-trihydroxyflavone) (en)
- 8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one (en)
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- 6358 (xsd:nonNegativeInteger)
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- Skeletal formula (en)
- Ball-and-stick model of amentoflavone (en)
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- Amentoflavone molecule ball.png (en)
- Amentoflavone.svg (en)
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- 3 (xsd:integer)
- Didemethyl-ginkgetin (en)
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- L'amentoflavone è un flavone presente in numerose piante tra cui Ginkgo biloba, Chamaecyparis obtusa, Hypericum perforatum e Xerophyta plicata. (it)
- Amentoflavone is a biflavonoid (bis-apigenin coupled at 8 and 3' positions, or 3′,8′′-biapigenin) constituent of a number of plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Hypericum perforatum (St. John's Wort) and Xerophyta plicata. Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body. It is also an inhibitor of human cathepsin B. (en)
- Amentoflavona es un biflavonoide (bis-apigenina) constitutivo de un número de plantas, incluyendo Ginkgo biloba, Chamaecyparis obtusa, Hypericum perforatum) y Xerophyta plicata. Amentoflavona puede interactuar con muchos medicamentos por ser un potente inhibidor de CYP3A4 y CYP2C9, que son las enzimas responsables del metabolismo de algunos fármacos en el organismo. También es un inhibidor de la catepsina B humana. (es)
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- Amentoflavone (en)
- Amentoflavona (es)
- Amentoflavone (it)
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