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- 5-Carboxamidotryptamin (5-CT) ist ein Tryptaminderivat, das eng mit dem Neurotransmitter Serotonin verwandt ist. 5-CT wirkt als nicht-selektiver, hochaffiner Vollagonist an den 5-HT1A-, 5-HT1B-, , und sowie mit geringerer Affinität an den 5-HT2-, und . Er hat eine vernachlässigbare Affinität zu den 5-HT1E- und 5-HT1F-Rezeptoren. 5-CT bindet am stärksten an den 5-HT1A-Rezeptor und es wurde einst angenommen, dass es für diese Stelle selektiv ist. (de)
- 5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin. 5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as at the 5-HT2, 5-HT3, 5-HT6 receptors with lower affinity. It has negligible affinity for the 5-HT1E and 5-HT1F receptors. 5-CT binds most strongly to the 5-HT1A receptor and it was once thought to be selective for this site. Recently, a close derivative of 5-CT, AH-494 has been shown to function as an agonist of 5-HT7, although being more selective over 5-HT1A. Structural study indicated residue Ser5x43 might play critical roles in the selectivity of 5-CT across the serotonin receptor family. (en)
- A 5-Carboxamidotriptamina (5-CT) é uma droga que actua como agonista não-selectivo em diferentes receptores de serotonina. Era inicialmente pensado que seria selectivo para o 5HT1, mas pesquisas posteriores mostraram que também actua no 5HT2, no 5HT3, no 5HT5 e no 5HT7, sendo no entanto o seu efeito maior no subtipo 5HT1A. Apesar da sua falta de selectividade, a 5-CT é ainda um composto útil e é grandemente usado em pesquisas científicas. (pt)
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- 5-Carboxamidotryptamin (5-CT) ist ein Tryptaminderivat, das eng mit dem Neurotransmitter Serotonin verwandt ist. 5-CT wirkt als nicht-selektiver, hochaffiner Vollagonist an den 5-HT1A-, 5-HT1B-, , und sowie mit geringerer Affinität an den 5-HT2-, und . Er hat eine vernachlässigbare Affinität zu den 5-HT1E- und 5-HT1F-Rezeptoren. 5-CT bindet am stärksten an den 5-HT1A-Rezeptor und es wurde einst angenommen, dass es für diese Stelle selektiv ist. (de)
- 5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin. 5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 receptors, as well as at the 5-HT2, 5-HT3, 5-HT6 receptors with lower affinity. It has negligible affinity for the 5-HT1E and 5-HT1F receptors. 5-CT binds most strongly to the 5-HT1A receptor and it was once thought to be selective for this site. Recently, a close derivative of 5-CT, AH-494 has been shown to function as an agonist of 5-HT7, although being more selective over 5-HT1A. Structural study indicated residue Ser5x43 might play critical roles in the selectivity of 5-CT across the serotonin receptor family. (en)
- A 5-Carboxamidotriptamina (5-CT) é uma droga que actua como agonista não-selectivo em diferentes receptores de serotonina. Era inicialmente pensado que seria selectivo para o 5HT1, mas pesquisas posteriores mostraram que também actua no 5HT2, no 5HT3, no 5HT5 e no 5HT7, sendo no entanto o seu efeito maior no subtipo 5HT1A. Apesar da sua falta de selectividade, a 5-CT é ainda um composto útil e é grandemente usado em pesquisas científicas. (pt)
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- 5-Carboxamidotryptamin (de)
- 5-Carboxamidotryptamine (en)
- 5-Carboxamidotriptamina (pt)
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