About: 4-Aminopyridine

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4-Aminopyridine (4-AP, fampridine, dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used as a research tool in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. It was undergoing Phase III clinical trials as of 2008, and the U.S. Food and Drug Administration (FDA) approved the compound on January 22, 2010. Fampridine is also marketed as Ampyra (pronounced "am-PEER-ah," according to the maker's website) in the United States by Acorda Therapeutics and as Fampyra in the European Union, Canada, and Australia. In

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  • La fampridina (nom comercial Fampyra ® ; fabricant Biogen) és un [fàrmac] del grup dels bloquejadors de canals de potassi reversibles. Fou el primer principi actiu autoritzat en totes les formes d’ esclerosi múltiple (EM) per a la millora de la capacitat de caminar dels pacients adults amb EM (EDSS 4-) 7). Químicament, la substància és una aminopiridina . (ca)
  • 4-أمينو البيريدين مركب عضوي له الصيغة الكيميائية C5H6N2، ويوجد على شكل بلورات عديمة اللون. يعد المركب واحداً من متصاواغات أمينو البيريدين. ويعد أيضاً من العقاقير الدوائية المستخدمة في علاج بعض أنواع التصلب المتعدد. (ar)
  • 4-Aminopyridine (4-AP, fampridine, dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used as a research tool in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. It was undergoing Phase III clinical trials as of 2008, and the U.S. Food and Drug Administration (FDA) approved the compound on January 22, 2010. Fampridine is also marketed as Ampyra (pronounced "am-PEER-ah," according to the maker's website) in the United States by Acorda Therapeutics and as Fampyra in the European Union, Canada, and Australia. In Canada, the medication has been approved for use by Health Canada since February 10, 2012. (en)
  • Fampridin (Handelsname Fampyra®; Hersteller Biogen) ist ein Arzneistoff aus der Gruppe der reversiblen Kaliumkanal-Blocker, der als erstes Medikament bei allen Verlaufsformen der Multiplen Sklerose (MS) zur Verbesserung der Gehfähigkeit von erwachsenen MS-Patienten (EDSS 4–7) eingesetzt wird. Chemisch ist der Stoff den Aminopyridinen zuzuordnen. (de)
  • La 4-aminopyridine (dalfampridine ou fampridine) est un composé organique aromatique dérivé de la pyridine de formule chimique H2NC5H4N. C'est l'isomère para de l'. Elle est principalement utilisée comme outil de recherche, afin de caractériser les sous-types de canal potassique. Elle a aussi été utilisée pour traiter certains symptômes de la sclérose en plaques mais n'a prouvé son efficacité que pour une amélioration symptomatique de la marche, où elle a été le plus étudiée . (fr)
  • La 4-amminopiridina (o, meno correttamente, 'aminopiridina', 4-AP, denominazione comune internazionale fampridina, dalfampridine) è una delle tre amminopiridine isomere. (it)
  • 4-氨基吡啶（4-AP）是一种有机化合物，化学式为C5H6N2。有3种同分异构体，被用作表征钾通道亚型的研究工具，也被用作用于治疗多发性硬化症的一些症状的药物，并且表面上对患有一些疾病的成年人行走症状有改善。 (zh)
dbo:alternativeName
  • 4-Pyridinamine (en)
  • 4-Pyridylamine (en)
  • dalfampridine (USAN) (en)
  • fampridine (INN) (en)
dbo:iupacName
  • Pyridin-4-amine (en)
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dbp:dailymedid
  • Dalfampridine (en)
dbp:drugName
  • Fampridine (en)
dbp:drugbank
  • DB06637 (en)
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  • 4 (xsd:integer)
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  • 14 (xsd:integer)
dbp:medlineplus
  • a611005 (en)
dbp:othernames
  • 4 (xsd:integer)
  • dalfampridine (en)
  • fampridine (en)
dbp:pin
  • Pyridin-4-amine (en)
dbp:tradename
  • Ampyra, Fampyra, others (en)
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  • 477221003 (xsd:integer)
dbp:watchedfields
  • changed (en)
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rdfs:comment
  • La fampridina (nom comercial Fampyra ® ; fabricant Biogen) és un [fàrmac] del grup dels bloquejadors de canals de potassi reversibles. Fou el primer principi actiu autoritzat en totes les formes d’ esclerosi múltiple (EM) per a la millora de la capacitat de caminar dels pacients adults amb EM (EDSS 4-) 7). Químicament, la substància és una aminopiridina . (ca)
  • 4-أمينو البيريدين مركب عضوي له الصيغة الكيميائية C5H6N2، ويوجد على شكل بلورات عديمة اللون. يعد المركب واحداً من متصاواغات أمينو البيريدين. ويعد أيضاً من العقاقير الدوائية المستخدمة في علاج بعض أنواع التصلب المتعدد. (ar)
  • Fampridin (Handelsname Fampyra®; Hersteller Biogen) ist ein Arzneistoff aus der Gruppe der reversiblen Kaliumkanal-Blocker, der als erstes Medikament bei allen Verlaufsformen der Multiplen Sklerose (MS) zur Verbesserung der Gehfähigkeit von erwachsenen MS-Patienten (EDSS 4–7) eingesetzt wird. Chemisch ist der Stoff den Aminopyridinen zuzuordnen. (de)
  • La 4-aminopyridine (dalfampridine ou fampridine) est un composé organique aromatique dérivé de la pyridine de formule chimique H2NC5H4N. C'est l'isomère para de l'. Elle est principalement utilisée comme outil de recherche, afin de caractériser les sous-types de canal potassique. Elle a aussi été utilisée pour traiter certains symptômes de la sclérose en plaques mais n'a prouvé son efficacité que pour une amélioration symptomatique de la marche, où elle a été le plus étudiée . (fr)
  • La 4-amminopiridina (o, meno correttamente, 'aminopiridina', 4-AP, denominazione comune internazionale fampridina, dalfampridine) è una delle tre amminopiridine isomere. (it)
  • 4-氨基吡啶（4-AP）是一种有机化合物，化学式为C5H6N2。有3种同分异构体，被用作表征钾通道亚型的研究工具，也被用作用于治疗多发性硬化症的一些症状的药物，并且表面上对患有一些疾病的成年人行走症状有改善。 (zh)
  • 4-Aminopyridine (4-AP, fampridine, dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used as a research tool in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. It was undergoing Phase III clinical trials as of 2008, and the U.S. Food and Drug Administration (FDA) approved the compound on January 22, 2010. Fampridine is also marketed as Ampyra (pronounced "am-PEER-ah," according to the maker's website) in the United States by Acorda Therapeutics and as Fampyra in the European Union, Canada, and Australia. In (en)
rdfs:label
  • 4-أمينو البيريدين (ar)
  • Fampridina (ca)
  • Fampridin (de)
  • 4-Aminopyridine (en)
  • 4-Aminopiridino (eo)
  • 4-Amminopiridina (it)
  • 4-Aminopyridine (fr)
  • 4-氨基吡啶 (zh)
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