The 2022 monkeypox outbreak in Italy is part of the larger outbreak of human monkeypox caused by the West African clade of the monkeypox virus. Italy was the sixth country, outside of the African countries with endemic monkeypox, to experience an outbreak in 2022. The first case was documented in Rome, Italy, on May 19, 2022. As of August 5th, Italy has 505 cases.