The 2021–22 Scottish Junior Cup was the 135th season of the Scottish Junior Cup, the national knockout tournament for member clubs of the Scottish Junior Football Association (SJFA). A total of 110 clubs initially entered the competition, reduced from 132 in 2019–20, mainly due to more teams joining the East of Scotland League and clubs that did not retain SJFA membership after moving to the West of Scotland League. In addition, Annbank United, Buckie Rovers, Spey Valley United, and Pumpherston Juniors did not compete.