This HTML5 document contains 58 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

Prefix	IRI
dcterms	http://purl.org/dc/terms/
dbo	http://dbpedia.org/ontology/
foaf	http://xmlns.com/foaf/0.1/
n18	https://global.dbpedia.org/id/
umbel-rc	http://umbel.org/umbel/rc/
yago	http://dbpedia.org/class/yago/
dbt	http://dbpedia.org/resource/Template:
rdfs	http://www.w3.org/2000/01/rdf-schema#
freebase	http://rdf.freebase.com/ns/
n14	http://commons.wikimedia.org/wiki/Special:FilePath/
n16	http://www.w3.org/2006/03/wn/wn20/instances/
rdf	http://www.w3.org/1999/02/22-rdf-syntax-ns#
owl	http://www.w3.org/2002/07/owl#
wikipedia-en	http://en.wikipedia.org/wiki/
dbc	http://dbpedia.org/resource/Category:
dbp	http://dbpedia.org/property/
prov	http://www.w3.org/ns/prov#
xsdh	http://www.w3.org/2001/XMLSchema#
wikidata	http://www.wikidata.org/entity/
dbr	http://dbpedia.org/resource/

Statements

Subject Item

dbr:Nucleus_raphe_magnus

rdf:type

owl:Thing yago:BodyPart105220461 umbel-rc:AnimalBodyPart yago:NeuralStructure105462674 yago:Brain105481095 umbel-rc:Brain yago:Thing100002452 wikidata:Q4936952 yago:Structure105225602 dbo:AnatomicalStructure dbo:Brain yago:PhysicalEntity100001930 yago:Part109385911

rdfs:label

Nucleus raphe magnus

rdfs:comment

The nucleus raphe magnus (called the nucleus raphes magnus by Terminologia Anatomica and some scientific publications), is located directly rostral to the nucleus raphe obscurus, and receives input from the spinal cord and cerebellum. This makes the nucleus raphe magnus a likely candidate for part of the motor system; however, it seems to participate in the endogenous analgesia system. Mounting evidence suggests that the nucleus raphe magnus plays an important role in homeostatic regulation. All of these brain areas influence the main function of the nucleus raphe magnus.

foaf:name

Nucleus raphe magnus nucleus raphe magnus

dbp:name

Nucleus raphe magnus

foaf:depiction

n14:Gray694.png

dcterms:subject

dbc:Medulla_oblongata dbc:Serotonin

dbo:wikiPageID

4469227

dbo:wikiPageRevisionID

886131413

dbo:wikiPageWikiLink

dbr:Spinothalamic_tract dbr:Hypothalamic dbr:Paraventricular_hypothalamic_nucleus dbr:Serotonin dbr:Raphe_nuclei dbr:Posterior_horn_of_spinal_cord dbc:Serotonin dbr:Analgesia dbr:Periaqueductal_grey_matter dbr:Spinal_cord dbr:Amygdala dbr:Motor_system dbr:Naloxone dbr:Parvocellular_reticular_nucleus dbr:Enkephalin dbr:Receptor_antagonist dbr:Terminologia_Anatomica dbr:Nucleus_raphe_obscurus dbc:Medulla_oblongata dbr:Cerebellum dbr:Antinociceptic

owl:sameAs

freebase:m.0c467r wikidata:Q17143534 n18:gBeA

dbp:wikiPageUsesTemplate

dbt:Infobox_brain dbt:Rhombencephalon dbt:Authority_control

dbo:thumbnail

n14:Gray694.png?width=300

dbp:caption

Section of the medulla oblongata at about the middle of the olive.

dbo:abstract

The nucleus raphe magnus (called the nucleus raphes magnus by Terminologia Anatomica and some scientific publications), is located directly rostral to the nucleus raphe obscurus, and receives input from the spinal cord and cerebellum. This makes the nucleus raphe magnus a likely candidate for part of the motor system; however, it seems to participate in the endogenous analgesia system. Mounting evidence suggests that the nucleus raphe magnus plays an important role in homeostatic regulation. The nucleus raphe magnus receives descending afferents from the periaqueductal grey matter (PAG), the paraventricular hypothalamic nucleus, central nucleus of the amygdala, lateral hypothalamic area, parvocellular reticular nucleus and the prelimbic, infralimbic, medial and lateral precentral cortices. All of these brain areas influence the main function of the nucleus raphe magnus. The main function of the nucleus raphe magnus is mostly pain mediation; in fact it sends projections to the dorsal horn of the spinal cord to directly inhibit pain. The nucleus raphe magnus releases serotonin when stimulated. Raphe-spinal neurons project to enkephalin releasing interneurons in the posterior horn of the spinal cord. The periaqueductal grey matter, an area of the brain involved in mediating analgesia, sends efferent connections to the nucleus raphe magnus when it is stimulated by opiates (endogenous or otherwise). Electrical stimulation of the PAG produces analgesia, as well as administration of morphine to the PAG or nucleus raphe magnus. The antinociceptic effects of electrical stimulation of the PAG can be blocked by administering naloxone, an opiate antagonist, to the nucleus raphe magnus. Similarly, afferent fibres from the spinothalamic tract synapse at the periaqueductal grey matter. This in turn is linked to the nucleus raphe magnus, which when stimulated directly inhibits pain fibers in the dorsal horn of the spinal cord, thus alleviating pain. All of this seems to indicate that the nucleus raphe magnus is part of the endogenous opiate system, and acts to inhibit pain in the spinal cord.

dbp:latin

nucleus raphe magnus

dbp:wordnet_type

n16:synset-brain-noun-1

prov:wasDerivedFrom

wikipedia-en:Nucleus_raphe_magnus?oldid=886131413&ns=0

dbo:wikiPageLength

4042

foaf:isPrimaryTopicOf

wikipedia-en:Nucleus_raphe_magnus