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Statements

Subject Item
dbr:Cryptic_relatedness
rdfs:label
Cryptic relatedness
rdfs:comment
In population genetics, cryptic relatedness occurs when individuals in a genetic association study are more closely related to another population than assumed by the investigators. This can act as a confounding factor in both case-control and genome-wide association studies, as well as in studies of genetic diversity. Along with population stratification, it is one of the most prominent confounding factors that can lead to inflated false positive rates in gene-association studies. It is often corrected for by including a polygenic component in the statistical model being used to detect genetic associations. Other approaches that have been developed to attempt to control for cryptic relatedness are the genomic control method and the use of extended likelihood ratio tests.
dct:subject
dbc:Medical_genetics dbc:Population_genetics dbc:Statistical_genetics
dbo:wikiPageID
59493276
dbo:wikiPageRevisionID
1040610770
dbo:wikiPageWikiLink
dbc:Population_genetics dbr:Statistical_model dbc:Statistical_genetics dbr:Genetic_association dbr:Genome-wide_association_study dbr:Genomic_control dbr:Case-control dbr:Population_stratification dbr:Confounding_factor dbr:Genetic_diversity dbr:Likelihood_ratio_test dbc:Medical_genetics dbr:Population_genetics dbr:Polygenic dbr:False_positive
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dbo:abstract
In population genetics, cryptic relatedness occurs when individuals in a genetic association study are more closely related to another population than assumed by the investigators. This can act as a confounding factor in both case-control and genome-wide association studies, as well as in studies of genetic diversity. Along with population stratification, it is one of the most prominent confounding factors that can lead to inflated false positive rates in gene-association studies. It is often corrected for by including a polygenic component in the statistical model being used to detect genetic associations. Other approaches that have been developed to attempt to control for cryptic relatedness are the genomic control method and the use of extended likelihood ratio tests.
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wikipedia-en:Cryptic_relatedness?oldid=1040610770&ns=0
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3105
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wikipedia-en:Cryptic_relatedness