About: Stichodactyla toxin

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Stichodactyla toxin (ShK, ShkT) is a 35-residue basic peptide from the sea anemone Stichodactyla helianthus that blocks a number of potassium channels. Related peptides form a conserved family of protein domains known as the ShkT domain. Another well-studied toxin of the family is BgK from . An analogue of ShK called ShK-186 or Dalazatide is in human trials as a therapeutic for autoimmune diseases.

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  • Stichodactyla toxin (ShK, ShkT) is a 35-residue basic peptide from the sea anemone Stichodactyla helianthus that blocks a number of potassium channels. Related peptides form a conserved family of protein domains known as the ShkT domain. Another well-studied toxin of the family is BgK from . An analogue of ShK called ShK-186 or Dalazatide is in human trials as a therapeutic for autoimmune diseases. (en)
dbo:symbol
  • ShK
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dbo:wikiPageID
  • 19690563 (xsd:integer)
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  • 77506 (xsd:nonNegativeInteger)
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  • 1048565136 (xsd:integer)
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  • Rainbow colored cartoon diagram of an NMR solution structure of the ShK toxin. Sidechains of cysteine residues involved in disulfide linkages are displayed as sticks and the sulfur atoms in these links are colored yellow. (en)
dbp:interpro
  • IPR003582 (en)
dbp:name
  • Kappa-stichotoxin-She3a (en)
  • ShK domain-like (en)
dbp:opmFamily
  • 296 (xsd:integer)
dbp:opmProtein
  • 2 (xsd:integer)
dbp:organism
  • Stichodactyla helianthus (en)
dbp:pfam
  • PF01549 (en)
dbp:scop
  • 1 (xsd:integer)
dbp:smart
  • SM00254 (en)
dbp:symbol
  • ShK (en)
dbp:tcdb
  • 8 (xsd:integer)
dbp:uniprot
  • P29187 (en)
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  • Stichodactyla toxin (ShK, ShkT) is a 35-residue basic peptide from the sea anemone Stichodactyla helianthus that blocks a number of potassium channels. Related peptides form a conserved family of protein domains known as the ShkT domain. Another well-studied toxin of the family is BgK from . An analogue of ShK called ShK-186 or Dalazatide is in human trials as a therapeutic for autoimmune diseases. (en)
rdfs:label
  • Stichodactyla toxin (en)
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