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- What does "highly evolved" mean? Strange phrasing. (en)
- **This is example is not clear can someone please translate to layman's terms?**"For example, self cleaving ribozyme RNAs and RNase A proteins both cleave phosphate backbones. However, the mechanisms differs. While the RNase A protein uses a coordinating histidine and lysine to attack the backbone, self cleaving ribozyme RNAs carry out an in-line SN2 reaction using the 2’ hydroxyl group as a nucleophile attacking the bridging phosphate and causing 5’ oxygen of the N+1 base to act as a leaving group." (en)
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