Vermont Route 78 (VT 78) is a 21.126-mile-long (33.999 km) east–west state highway in northwestern Vermont, United States. It begins at U.S. Route 2 (US 2) in Alburgh near the New York and Canada–US borders, and runs southeast to VT 105 in Sheldon. It is one of two routes connecting the Vermont mainland to the Grand Isle area of Lake Champlain, the other being US 2 north of Burlington.