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About: Variant surface glycoprotein     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatProtistProteins, within Data Space : dbpedia.org associated with source document(s)

Type: yago:Abstraction100002137yago:Chemical114806838yago:Compound114818238yago:ConjugatedProtein114731135yago:Glycoprotein114888310yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Molecule114682133yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Protein114728724yago:Relation100031921yago:WikicatGlycoproteinsproteinyago:Substance100019613yago:Thing100002452yago:Unit109465459yago:WikicatProtistProteins New Facet based on Instances of this Class

Variant surface glycoprotein (VSG) is a ~60kDa protein which densely packs the cell surface of protozoan parasites belonging to the genus Trypanosoma. This genus is notable for their cell surface proteins. They were first isolated from Trypanosoma brucei in 1975 by George Cross. VSG allows the trypanosomatid parasites to evade the mammalian host's immune system by extensive antigenic variation. They form a 12–15 nm surface coat. VSG dimers, ~90% of all cell surface protein. It also makes up ~10% of total cell protein. For this reason, these proteins are highly immunogenic and an immune response raised against a specific VSG coat will rapidly kill trypanosomes expressing this variant. However, with each cell division there is a possibility that the progeny will switch expression to change t