U.S. Route 40 (US 40) enters Pennsylvania at West Alexander. It closely parallels Interstate 70 (I-70) from West Virginia until it reaches Washington, where it follows Jefferson Avenue and Maiden Street.In Washington, US 40 passes to the south of Washington & Jefferson College. Following Maiden Street out of town, the road turns southeast toward the town of California. A short limited access highway in California and West Brownsville provides an approach to the Lane Bane Bridge across the Monongahela River. From here, the road continues southeast to Uniontown.