Sterkspruit is a town in the Senqu Local Municipality in the Joe Gqabi District Municipality in the Eastern Cape province of South Africa. The town is located about 45 km south-east of Zastron, 80 km north-east of Aliwal North, and 24 km from the Lesotho border. It takes its name from the Sterkspruit, the watercourse on which it is situated. The name is Afrikaans and means ‘strong stream’.