The siege of Ghent during the Eighty Years' War by Spanish general Alexander Farnese, Prince of Parma, lasted from October 1583 to 17 September 1584. It was the end phase of the so-called Calvinist Republic of Ghent, which had controlled most of the County of Flanders since radical Protestants seized power on 28 October 1577, claiming a leading role for the city of Ghent in the struggle against the Spanish royal forces and Malcontent Catholics.