Señorita Panamá 2021 was the 55th Señorita Panamá pageant. It selected the national representatives to the Miss Universe, Miss Supranational, and Miss Grand International competitions. This was the sixth edition of the renewed Señorita Panama pageant, under the direction of Cesar Anel Rodríguez, who took charge of the national event in 2016. Twenty nine preliminary contestants were selected from throughout Panama and competed for the crown. The 2021 edition was held, for the first time, Hotel Whyndham Convention Center, in Panama City on November 7, 2021.