Pennsylvania Route 272 (PA 272) is a 54.7-mile-long (88.0 km) highway in southeastern Pennsylvania, in the Lancaster area. The southern terminus of the route is at the Mason–Dixon line southeast of Nottingham, where the road continues into Maryland as Maryland Route 272 (MD 272). The northern terminus is at an interchange with U.S. Route 222 (US 222) and PA 568 near Adamstown, where PA 568 continues east. The route heads from the Maryland border northwest through the western corner of Chester County, intersecting US 1 in Nottingham. PA 272 continues west into Lancaster County and intersects US 222 in Wakefield, where it turns north and passes through Buck before widening into a divided highway as it comes to another junction with US 222 in Willow Street. Here, the route becomes unsigned an