About: Nuclear cap-binding protein complex

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Nuclear cap-binding protein complex is a RNA-binding protein which binds to the 5' cap of pre-mRNA. The cap and nuclear cap-binding protein have many functions in mRNA biogenesis including splicing, 3'-end formation by stabilizing the interaction of the 3'-end processing machinery, nuclear export and protection of the transcripts from nuclease degradation. When RNA is exported to the cytoplasm the nuclear cap-binding protein complex is replaced by cytoplasmic cap binding complex. The nuclear cap-binding complex is a functional heterodimer and composed of Cbc1/Cbc2 in yeast and CBC20/CBC80 in multicellular eukaryotes. Human nuclear cap-binding protein complex shows the large subunit, CBC80 consists of 757 amino acid residues. Its secondary structure contains approximately sixty percent of h

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Chemical114806838 yago:Cognition100023271 yago:Complex105870365 yago:Compound114818238 yago:Concept105835747 yago:Content105809192 yago:Idea105833840 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:PsychologicalFeature100023100 yago:Relation100031921 protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:Whole105869584 yago:WikicatProteinComplexes yago:WikicatRNA-bindingProteins umbel-rc:ProteinMolecule
rdfs:label	Cap-Binding-Komplex (de) Nuclear cap-binding protein complex (en)
rdfs:comment	Der Cap-Binding-Komplex (CBC), genauer der nukleäre Cap-Binding-Komplex (NCBC), ist ein aus zwei Untereinheiten bestehender Proteinkomplex, der im Zellkern von Eukaryoten an die 5'-Cap-Struktur der entstehenden mRNA bindet. Die Bindung von CBC stabilisiert die RNA und schützt sie vor der Entfernung der m7G-Cap; außerdem führt sie nach Transkriptionsende dazu, dass der Poly-A-Schwanz eine Bindung eingeht, und so die RNA cyclisiert wird und noch weniger Angriffsfläche bietet. Weiterhin ist der CBC unentbehrlich für den Prozess des Spleißens und den Transport aus dem Zellkern zum endoplasmatischen Reticulum. Der CBC bei Metazoen besteht aus den Untereinheiten CBP20 und CBP80, die Benennung erfolgte anhand der Molekülmasse von 20 kDa bzw. 80 kDa. Bei Hefen werden die Untereinheiten als CBC1 un (de) Nuclear cap-binding protein complex is a RNA-binding protein which binds to the 5' cap of pre-mRNA. The cap and nuclear cap-binding protein have many functions in mRNA biogenesis including splicing, 3'-end formation by stabilizing the interaction of the 3'-end processing machinery, nuclear export and protection of the transcripts from nuclease degradation. When RNA is exported to the cytoplasm the nuclear cap-binding protein complex is replaced by cytoplasmic cap binding complex. The nuclear cap-binding complex is a functional heterodimer and composed of Cbc1/Cbc2 in yeast and CBC20/CBC80 in multicellular eukaryotes. Human nuclear cap-binding protein complex shows the large subunit, CBC80 consists of 757 amino acid residues. Its secondary structure contains approximately sixty percent of h (en)
foaf:name	Nuclear cap binding protein subunit 2, 20kDa (en) nuclear cap-binding protein complex (en)
name	Nuclear cap binding protein subunit 2, 20kDa (en) nuclear cap-binding protein complex (en)
foaf:depiction
dcterms:subject	RNA-binding proteins
Wikipage page ID	11835253 (xsd:integer)
Wikipage revision ID	1032227842 (xsd:integer)
Link from a Wikipage to another Wikipage	Messenger RNA Beta sheet Cytoplasm Small nuclear RNA Alpha helix Amino acid RNA-binding proteins Biomolecular structure RNA-binding protein Biogenesis Amino acid residue 5' cap Heterodimer Pre-mRNA
sameAs	Nuclear cap-binding protein complex Nuclear cap-binding protein complex Nuclear cap-binding protein complex Nuclear cap-binding protein complex Nuclear cap-binding protein complex
dbp:wikiPageUsesTemplate	dbt:MeshName dbt:Protein-stub dbt:Reflist dbt:Short_description dbt:Infobox_protein
thumbnail	wiki-commons:Special:FilePath/1H6K.pdb.jpg?width=300
OMIM	605133 (xsd:integer)
AltSymbols	NCBP (en)
caption	Crystal structure of the human nuclear cap-binding complex. (en)
symbol	NCBP1 (en) NCBP2 (en)
UniProt	P52298 (en)
has abstract	Der Cap-Binding-Komplex (CBC), genauer der nukleäre Cap-Binding-Komplex (NCBC), ist ein aus zwei Untereinheiten bestehender Proteinkomplex, der im Zellkern von Eukaryoten an die 5'-Cap-Struktur der entstehenden mRNA bindet. Die Bindung von CBC stabilisiert die RNA und schützt sie vor der Entfernung der m7G-Cap; außerdem führt sie nach Transkriptionsende dazu, dass der Poly-A-Schwanz eine Bindung eingeht, und so die RNA cyclisiert wird und noch weniger Angriffsfläche bietet. Weiterhin ist der CBC unentbehrlich für den Prozess des Spleißens und den Transport aus dem Zellkern zum endoplasmatischen Reticulum. Der CBC bei Metazoen besteht aus den Untereinheiten CBP20 und CBP80, die Benennung erfolgte anhand der Molekülmasse von 20 kDa bzw. 80 kDa. Bei Hefen werden die Untereinheiten als CBC1 und CBC2 bezeichnet. Zu den genannten Funktionen kommt, dass mRNA durch die Bindung an CBC auch während der ersten Runde der Translation vor dem Abbau durch geschützt wird. (de) Nuclear cap-binding protein complex is a RNA-binding protein which binds to the 5' cap of pre-mRNA. The cap and nuclear cap-binding protein have many functions in mRNA biogenesis including splicing, 3'-end formation by stabilizing the interaction of the 3'-end processing machinery, nuclear export and protection of the transcripts from nuclease degradation. When RNA is exported to the cytoplasm the nuclear cap-binding protein complex is replaced by cytoplasmic cap binding complex. The nuclear cap-binding complex is a functional heterodimer and composed of Cbc1/Cbc2 in yeast and CBC20/CBC80 in multicellular eukaryotes. Human nuclear cap-binding protein complex shows the large subunit, CBC80 consists of 757 amino acid residues. Its secondary structure contains approximately sixty percent of helical and one percent of beta sheet in the strand. The small subunit, CBC20 has 98 amino acid residues. Its secondary structure contains approximately twenty percent of helical and twenty-four percent of beta sheet in the strand. Human nuclear cap-binding protein complex plays important role in the maturation of pre-mRNA and in uracil-rich small nuclear RNA. (en)
Arm	q (en)
band	29 (xsd:integer) 34.100000 (xsd:double)
Chromosome	3 (xsd:integer) 9 (xsd:integer)
EntrezGene	4686 (xsd:integer) 22916 (xsd:integer)
HGNCid	7658 (xsd:integer) 7659 (xsd:integer)
RefSeq	NM_002486 (en) NM_007362 (en)
gold:hypernym	Protein
arm	q
band	29 34.1
chromosome	3 9
EntrezGene	22916 4686
HGNCid	7659 7658
RefSeq	NM_002486 NM_007362
UniProt	P52298
prov:wasDerivedFrom	wikipedia-en:Nuclear_cap-binding_protein_complex?oldid=1032227842&ns=0

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