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Neurokinin 1 (NK1) antagonists (-pitants) are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties. NK-1 antagonists boost the efficacy of 5-HT3 antagonists to prevent nausea and vomiting. The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of nausea and vomiting associated with cancer chemotherapy. The first registered clinical use of NK1 receptor antagonists was the treatment of emesis, associated with cancer chemotherapy.

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  • مناهضات مستقبلات إن كي1 (ar)
  • Antagoniste des récepteurs NK1 (fr)
  • NK1 receptor antagonist (en)
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  • Les antagonistes du récepteur de la neurokinine-1 sont une classe thérapeutique à actions antiémétique, antidépresseur et anxiolytique, qui agit par blocage de la fixation de la substance P sur les récepteurs de la neurokinine 1. (fr)
  • مناهضات التاخيكينين 1 (إن كي1) هي فئة جديدة من الأدوية التي تمتلك خصائص فريدة مضادة للاكتئاب والقلق ومضادة للقئ. تعمل مضادات إن كي1على تعزيز فعالية مناهضات مستقبلات السيروتونين في منع الغثيان والقيء. كان اكتشاف مناهضات مستقبلات التاخيكينين1 (إن كي1) نقطة تحول في الوقاية من الغثيان والقيء المرتبطين بالعلاج الكيميائي للسرطان. كان أول استخدام سريري مُسجّل لمناهضات مستقبلات إن كي1هو علاج التقيؤ المرتبط بالعلاج الكيميائي للسرطان. (ar)
  • Neurokinin 1 (NK1) antagonists (-pitants) are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties. NK-1 antagonists boost the efficacy of 5-HT3 antagonists to prevent nausea and vomiting. The discovery of neurokinin 1 (NK1) receptor antagonists was a turning point in the prevention of nausea and vomiting associated with cancer chemotherapy. The first registered clinical use of NK1 receptor antagonists was the treatment of emesis, associated with cancer chemotherapy. (en)
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