Michele Pennisi (born 23 November 1946) is an Italian Archbishop of the Catholic Church in Sicily, and a noted opponent of the Sicilian Mafia. He served as Archbishop of Monreale from 8 February 2013 to 28 April 2022. Following reorganisation of the Sicilian church in 2000, Archbishops of Monreale are no longer Metropolitans, but they retain the personal rank of Archbishop.